2022 WHO Classification and Prognosis of Acute Myeloid Leukemia with Defining Genetic Abnormalities

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Last updated 6:25 AM on 5/6/26
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13 Terms

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APL with PML::RARA fusion

Long-term cure rates >90%

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AML with RUNX1::RUNX1T1 fusion

High rates of complete remission and disease-free survival

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AML with CBFB::MYH11 fusion

Favorable prognosis

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AML with DEK::NUP214 fusion

Poor prognosis

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AML with RBM15::MRTFA fusion

No uniform prognosis

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AML with BCR::ABL1 fusion

Poor response to standard induction chemotherapy

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AML with KMT2A rearrangement

Prognosis depends on fusion partner

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AML with MECOM rearrangement

Aggressive disease with short survival

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AML with NUP98 rearrangement

Poor prognosis

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AML with NPM1 mutation

Typically shows good response to standard chemotherapy

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AML with CEBPA mutation

Variable prognosis depending on CEBPA mutation type

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AML, myelodysplasia-related

Poor prognosis

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AML with other defined genetic alterations

Prognosis based on specific alteration