NEURO 3 (11) sec 4

anhedonia

inability to find pleasure in activities used to enjoy

how many genes implicated in depression

269

PET

used to measure glucose uptake in the brain

subgenual congugate

takes up less glucose when depressed and more when in mania

depression on sleep

reduction in slow-wave sleep

reduces memory

HPA Axis also becomes ______in depression

dysregulated

dexamethasone, a synthetic
molecule that is similar to cortisol, suppresses normal ______release through negative
feedback. This effect is not seen in people _____depression

cortisol

with

Depression is often treated with drugs that
work on

monoamine neurotransmitters

MAOIs inhibit

enzyme involved in breaking
down neurotransmitters. T

effectiveness of drugs that act on
monoamine systems has led to the

hypothesis
that depression is characterized by a deficit in
these neurotransmitters

Within the dentate gyrus, the _____
zone contains continuously dividing neural
_____ cells that can give rise to
newborn neurons.

subgranular

progenator

The subventricular zone of the lateral
ventricles also contains neural progenitor
cells. Cells born here migrate to the
_______

olfactory bulb

cortisol ____ neurogenesis, whereas monoamines ____ neurogenesis

inhibit

promote

Cognition can be used to do what

alter mood

ECT

used for extreme cases of treatment resistant depression

TMS

generate small magnetic field to stimulate regions of the brain

ketamine

recent:

antagonizes glutamate at NMDA receptor

Vagus nerve stimulation

primary parasympathetic nerve of the body

electrical stimulation habits the sympathetic nervous system which may balance out a dysregulated stress response