PDA III - Exam 3 (names/moa)

amitriptyline, nortriptyline, doxepin, imipramine, clomipramine

TCAs: reuptake inhibitors of NE and 5-HT

fluoxetine, (es)citalopram, fluvoxamine, sertraline, paroxetine, vortioxetine

SSRIs: selective serotonin reuptake inhibitors

(des)Venlafaxine, duloxetine, levomilnacipran

SNRIs: reuptake inhibitor of NE and 5-HT

Trazodone

5HT reuptake blocker

Mirtazapine

a2 antagonist, 5HT antagonist, H1 antagonist

Buproprion

NDRI: NE and Dopamine reuptake inhibitor

Amphetamine

NDRI: NE and Dopamine reuptake inhibitor

tranylcypromine, Isocarboxazid, phenelzine

MAOIs: inhibit metabolism of NE and 5-HT

(Es)Ketamine

NMDA antagonist

Brexanolone, Zuranolone

neurosteroids: non-BDZ sensitive GABAa receptors; potentiate GABA at GABAa

Lithium

- Dec. Gq coupled protein signaling

- inhibits phosphatases that convert IP2 to IP1 (and IP1 --> inositol)

- dec. recyling

Carbamazepine - BPD

mania/mixed (mood stabilizer)

Valproic Acid - BPD

mania/mixed (mood stabilizer)

Lamotrigine - BPD

Maintenance (mood stabilizer)

Aripiprazole- BPD

mania/mixed, maintenance

Quetiapine - BPD

mania/mixed, depression, maintence

Quetiapine-fluoxetine - BPD

depression

risperidone - BPD

mania/mixed & maintenance

olanzapine - BPD

mania/mixed & maintenance

Lurasidone - BPD

depression

Cariprazine - BPD

mania/mixed, depression

LYBALVI: olanzapine/samidorphan - BPD

S: opioid antagonist that prevents O-induced weight gain

Barbiturate

Potentiate GABA at GABAa; hold channel open for longer

Benzodiazeapine

Potentiate GABA at GABAa; hold channel more frequently

Felbomate

NMDA receptor antagonist

Gabapentin

antagonist for HVA Ca2+ channel (closes channel)

Phenytoin, Carbamazepine, Lamotrigine

bind to inactivated voltage gated Na channel and prevent from opening (prolong refractory period)

Clonazepam

selective for GABAa receptors expressed in ???

potentiates GABA at GABAa

Ethosuximide

Bind to t-type CA channel and hold closed

valproic acid

- Bind to t-type CA channel and hold closed

- inhibit GABA-transferase (GABA-T) and succinic semialdehyde dehydrogenase --> prevent GABA metabolism

Tiagabine

Block GAT1 (GABA transporter) --> inc. GABA concentration in synapse

Vigabatrin

Diazepam, Lorazepam

for status epilepticus