PHSC1312 Microbiology/Immunology Lecture 4 Pathogen Recognition Receptors (PRRs)
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21 Terms
toll like, c type lectin, damage recognition
three extracellular receptors (PRRs)
toll like, nod like, rig I helicase like
three intracellular receptors (PRRs)
endosome
Where are TLRs 3, 7, 9?
plasma membrane
Where are TLRs 2, 4, and 5?
nucleic acids
What are the activating microbial ligands of TLRs 3, 7, and 9?
dsRNA
What is the activating microbial ligand of TLR3?
ssRNA
What is the activating microbial ligand of TLR7?
CpG DNA
What is the activating microbial ligand of TLR9?
peptidoglycan
What is the activating microbial ligand of TLR2?
lipopolysaccharide
What is the activating microbial ligand of TLR4?
flagellin
What is the activating microbial ligand of TLR5?
mannose
What is the activating microbial ligand of MBL, a type of CLR?
viral, fungal, and bacterial carbohydrate
What is mannose?
glucans
What is the activating microbial ligand of Dectin-1, a type of CLR?
peptidoglycan
What is the activating microbial ligand of NOD2, a type of NLR?
Staphylococcus alpha toxin
What is the activating microbial ligand of NLRP3, a type of NLR?
double stranded viral RNA
What is the activating microbial ligand of RIG-I, a type of RLR?
inflammatory cytokines and Type I interferons
What does TLR signal transduction activate?
bacteria and yeast
What type of microbe do c type lectin receptors recognize?
bacteria in the cytosol
What type of microbes do nod like receptors recognize?
viruses
What type of microbes do rig i helicase receptors recognize?