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Absolute contraindications for transplant
Untreated/metastatic cancer
Refractory Coronary artery or heart disease
Drug abuse
Severe psychiatric disease
3 types of donors
Deceased/cadaveric
Living Related
Living unrelated
Most common type of donation
Cadaveric
When does acute rejection develop?
During the first 3 months after the transplant (most common & treatable)
Manifestations of acute rejection
Fever
Swelling
Tenderness over graft site
Decreased urine output
Rise in Cr
Treatment for acute rejection
Increase doses of immunosuppressive medications
Complications of long-term immunosuppression
INFECTION
Tumors
Cancers
Infant congenital anomalies (use good birth control)
Corticosteroid use → bone problems