Hazardous Medications Part 1 and 2 (Kirk)

Explain the C-PEC that would be used for hazardous drug compounding:

-Vertical air flow

-Negative pressure

-Ventilated to the outdoors

-Class 5 ISO

What are the different PECs used for hazardous drugs?

-Biological safety cabinet

-Compounding aseptic containment isolators

-Containment ventilated enclosures

True or False: hazardous and nonhazardous drugs can be stored together

False

What kind of pressure must be in a room in which there is hazardous drugs?

Negative pressure

-This will keep hazardous air from getting out

In what case may a nonhazardous drug be stored with a hazardous drug?

If the HD is lower risk, and it is explicitly written in the Assessment of Risk

All personnel of _________________ capability must sign a document stating they have been informed of risks

Reproductive

When is training required for handling hazardous drugs?

1. Prior to working with HDs

2. New drugs, equipment, SOP

3. Annually

What are the main differences between USP 797 and USP 800 cleaning?

800: Deactivation and Decontamination

_______________ refers to rendering the compound inert or inactive, while ______________ means removing hazardous drug residue

Deactivation, Decontamination

Environmental wipe sampling for HD should be performed ______________, and then every ______________

Initially, 6 months

What is the key difference in eye protection between USP 797 and 800?

Googles +/- Face mask

What is the mask requirement for USP 800?

N95

True or False: an N95 must be worn according to USP 797

False: only USP 800

What is the glove requirement for USP 800?

Double gloves certified for HDs

True or False: a gown used when handling HDs can be reused

False

True or False: two shoe covers must be worn according to USP 800

True

What is the shoe covering requirement according to USP 800?

Double shoe covers

Where would the specific PPE requirements be found?

Documented in the SOP

True or False: the HD aseptic technique involves inject air into the vial before drug

False

What are the two ways that HD could be removed from the vial?

-Negative Pressure Method

-CSTD

True or False: the HD aseptic technique only requires wiping down products before they enter the hood

False: the product needs to be wiped before it enters and after it is taken out of the hood

Who is in charge of regulating Medical Waste disposal?

The Environmental Protective Agency (EPA) via the RCRA (Resource Conservatory and Recovery Act)

The Trace Chemo container is colored __________________, and the RCRA container is colored ________________

Yellow, Black

USP 800 creates guidance based on the _______________ list

NIOSH

What four chemical properties make a drug hazardous?

Ignitable, Corrosive, Toxic, Reactive