Common Reagents for Substitution and Elimination

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Last updated 9:05 PM on 4/14/26
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15 Terms

1
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Cl-

Halide: Strong nuc, weak base

2
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Br-

Halide: Strong nuc, weak base

3
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I-

Halide: Strong nuc, weak base

4
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H:-

Strong Base, weak nuc

5
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-OC(CH3)3 (aka -OtBu)

Strong base, weak nuc, (bulky) (technically strong base but sterically hindered so not nuc in most cases)

6
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-OH

Strong nuc, strong base

7
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MeO-

Strong nuc, strong base

8
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EtO-

Strong nuc, strong base

9
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H2O

Weak nuc, weak base

10
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MeOH

Weak nuc, weak base

11
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EtOH

Weak nuc, weak base

12
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HS-

Sulfur: strong nuc, weak base

13
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RS-

Sulfur: strong nuc, weak base

14
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H2S

Sulfur: strong nuc, weak base

15
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RSH

Sulfur: strong nuc, weak base