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Toxin produced?
Tetanospasmin

Mechanism of tetanus toxin?
Blocks GABA & glycine release (via SNARE cleavage)

How does toxin reach CNS?
Retrograde axonal transport

Type of paralysis?
Spastic paralysis

Classic symptoms?
Trismus (lockjaw), risus sardonicus, opisthotonos

Is tetanus invasive?
No (localized infection, toxin-mediated)

Prevention?
Tetanus vaccine (toxoid, DPT)

Treatment?
Antitoxin + antibiotics + diazepam + wound debridement

Mechanism of toxin?
Blocks ACh release (SNARE cleavage)

Type of paralysis?
Descending flaccid paralysis

5 D’s” of botulism?
Diplopia, dysarthria, dysphagia, dyspnea, descending paralysis

Sensory deficits present?
No

Infant botulism cause?
Spores (honey) → floppy baby

Adult botulism cause?
Preformed toxin (canned food)

Treatment
Human botulinum immunoglobulin

Clinical classification?
Intoxication (not infection)