NAPLEX Brand & Generic Drugs

Renvela

Sevelamer Carbonate

Calcium-free and aluminum free phosphate binder used to block the absorption of phosphate from the diet to treat hyperphosphatemia.

Renagel

Sevelamer Hydrochloride

Calcium-free and aluminum free phosphate binder used to block the absorption of phosphate from the diet to treat hyperphosphatemia.

Sensipar

Cinacalcet

Calcimimetic that increases the sensitivity of calcium receptor on the parathyroid gland, leading to reductions in parathyroid hormone

Mavyret

Glecaprevir/pibrentasvir

Direct acting antiviral for the treatment of hepatitis C virus (HCV) comprised of a NS3/4A protease inhibitor and a NS5A replication complex inhibitor

Epclusa

Sofosbuvir/velpatasvir

Direct acting antiviral for the treatment of hepatitis C virus (HCV) comprised of a NS5B polymerase inhibitor and a NS5A replication complex inhibitor

Viread

Tenofovir disoproxil fumarate (TDF)

This is a nucleotide reverse transcriptase inhibitor (NRTI) which prevents hepatitis B virus (HBV) replication by inhibiting HBV polymerase, which results in DNA chain termination.

This is also indicated for the treatment of HIV.

Vemlidy

Tenofovir alafenamide (TAF)

This is a nucleotide reverse transcriptase inhibitor (NRTI) which prevents hepatitis B virus (HBV) replication by inhibiting HBV polymerase, which results in DNA chain termination.

Baraclude

Entecavir

This is a nucleotide reverse transcriptase inhibitor (NRTI) which prevents hepatitis B virus (HBV) replication by inhibiting HBV polymerase, which results in DNA chain termination.

Sandostatin

Octreotide acetate

Synthetic somatostatin analog which is a vasoconstriction agent that reduces portal pressure and splanchnic (GI) blood flow and circulation

Corgard

Nadolol

Non-selective beta-blocker for primary and secondary prevention of variceal bleeding by lowering portal pressure (aka portal hypertension)

Inderal LA & Inderal XL

Propranolol

Non-selective beta-blocker for primary and secondary prevention of variceal bleeding by lowering portal pressure (aka portal hypertension)

Coreg

Carvedilol

Non-selective beta-blocker for primary and secondary prevention of variceal bleeding by lowering portal pressure (aka portal hypertension)

Xifaxan

Rifaximin

Antibiotic that treats hepatic encephalopathy by inhibiting the activity of urease-producing bacteria, which decreases ammonia production

Doryx; Vibramycin

Doxycycline

Antibiotic used for malarial prophylaxis

Bicillin L-A

Penicillin G Benzathine

Natural penicillin antibiotic for the treatment of syphilis

Augmentin; Augmentin ES-600

Amoxicillin/clavulanate

Aminopenicillin used as the first line treatment of acute otitis media and bacterial sinusitis

Penicillin V Potassium (aka penicillin VK)

Natural penicillin which is used as a first line treatment for pharyngitis (aka strep throat)

Amoxicillin

This is an aminopenicillin

First line treatment of acute otitis media

Drug of choice for infective endocarditis prophylaxis before dental procedures

Used in H. pylori treatment regimens

Dicloxacillin; Nafcillin; Oxacillin (these are all different medications)

Antistaphylococcal penicillin - cover MSSA but they lack activity against enterococcus.

Unasyn

Ampicillin/sulbactam

Ampicillin is an aminopenicillin that provides coverage against listeria.

Sulbactam is a beta-lactamase inhibitor which provides added coverage against MSSA and gram negative bacteria (Haemophilus influenzae, Neisseria, Proteus, E. coli, Klebsiella [HNPEK]) and gram negative anaerobes.

Zosyn

Piperacillin/tazobactam

This is an extended spectrum penicillin combined with a beta-lactamase inhibitor. They cover the same organisms as aminopenicillin/beta-lactamase inhibitors + has expanded coverage of other gram-negatives bacteria (Citrobacter, Acinetobacter, Providencia, Enterobacter, Serratia [CAPES]) and pseudomonas.

1st Generation Cephalosporins

Cefazolin and Cephalexin

Antibiotics that provides coverage for gram-positive cocci (streptococci and staphylococci), MSSA, and gram negative rods (Proteus, E. coli, Klebsiella [PEK])

Cephalexin is used for MSSA and strep throat

Cefazolin is used for surgical prophylaxis

2nd Generation Cephalosporins

Cefuroxime, Cefotetan, Cefoxitin

Antibiotics that cover Haemophilus influenzae, Neisseria, Proteus, E. coli, Klebsiella [HNPEK]

Cefuroxime is used for acute otitis media and community acquired pneumonia (CAP).

Cefotetan and Cefoxitin provides anaerobic coverage (B. fragilis) and can be used for surgical prophylaxis specifically for GI procedures.

Cefotetan can cause a disulfiram-like reaction with alcohol ingestion.

3rd Generation Cephalosporins (Group 1)

Ceftriaxone and Cefdinir

Antibiotics that cover resistant streptococci and resistant strains of Haemophilus influenzae, Neisseria, Proteus, E. coli, Klebsiella [HNPEK]

Cefdinir is used for acute otitis media

Ceftriaxone is used to treat CAP, meningitis, spontaneous bacterial peritonitis and pyelonephritis. No renal dose adjustments are required.

3rd Generation Cephalosporins (Group 2)

Ceftazidime - lacks gram positive activity but covers pseudomonas

4th Generation Cephalosporins

Cefepime - provides coverage against pseudomonas

5th Generation Cephalosporins

Ceftaroline Fosamil (Teflaro) - broad gram positive activity that covers MRSA

Commonly used for CAP and skin and soft tissue infections

Carbapenems

Ertapenem (Invanz) and Meropenem

Class Effect - ALL active against ESBL producing organisms and pseudomonas (except ertapenem)

Organism Not Covered (class effect) - Atypicals, VRE, MRSA, C.difficile, and stenotrophomonas.

Ertapenem (Invanz) - does not cover pseudomonas, enterococcus, and acinetobacter; must be diluted in normal saline

Commonly used for polymicrobial infections (severe diabetic foot infection, empiric therapy when resistant organisms are present, ESBL positive infections, and pseudomonas (except ertapenem)

Monobactam

Aztreonam (Azactam)

Covers gram negative organisms