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what 4 things need to be considered upon clinical use of NPs
administration
PK
biological barriers
safety
what are three directed local delivery options
brain infusion
dermal adminstration
mucosal delivery
2 types of molecular targeting
passive - NPs accumulate in target tissues
active - utilising affinity ligands on the surface of NCs for specific homing
what is temporal targeting
exploits therapeutic windows to maximise drug delivery