Disorder of primary hemostasis: number and function

a disorder of primary hemostasis usually occurs because of what two reasons

• thrombocytopenia

• impaired platelet function or vascular disease

what are common clinical signs of primary hemostasis disorders

• petechia

• ecchymoses

• bleeding from mucosal surfaces

• prolonged bleeding

what are the major causes of thrombocytopenia

• consumption

• destruction

• decreased production

consumption of platelets includes _________

hemorrhage

consumption of platelets due to hemorrhage will be accompanied by what lab result

regenerative anemia

what are common ways platelets are consumed

• hemorrhage

• DIC

• vasculitis

when an animals own immune system produces antibodies against its own platelets we can say that animal has __________________

immune mediated thrombocytopenia

ITP acts as a form of ___________ for platelets

destruction

when concurrent with IMHA, ITP and IMHA are known as what _______________

evan’s syndrome

what are the lab findings of a dog undergoing ITP

• increased MPV

• increased megakaryocytes

• macroplatelets

what are other causes of thrombocytopenia

• myelopthisis

• infectious agents

• drugs

• irradiation

thrombocytopenia not caused by ITP will see _____________ in circulation

no macro platelets

unlike in ITP other causes of thrombocytopenia will ________________ in the bone marrow

decrease megakaryocytes

what is often seen with decreased platelet production in the lab

• bicytopenia

• pancytopenia

Endothelial cells losing vWF prevents platlets from binding which would lead to __________________ namely ______________

• primary hemostatic disorders

• von Willebrand disease

dogs with von Willebrand disease have these specific traits

• normal platelet count

• prolonged buccal mucosal bleed time

• normal coag test

primary hemostatic disorders caused by abnormal platelet granulation is a inherited defect called what?

chediak-higashi syndrome

primary hemostatic disorder caused by a deficiency in GP2b-3a receptors is an inherited defect called what

Glanzmann throbasthenia

a reverse of von wilebrand disease in which the platelet lacks the GP1b receptor is called the what?

bernard soulier syndrome

drugs like aspirin or NSAIDs can cause primary hemostatic disorder by _________________ that allow for activation of platelet receptors needed for coagulation

inactivating enzymes

what are common causes of thrombocytosis

• physiologic

• inflammation

• neoplasm

physiologic thrombocytosis causes a release of _____________ which leads to _____________

• epinephrine

• splenic contraction

in physiologic thrombocytosis is platelet production increased

no

in reactive thrombocytosis inflammation causes ________________ to increase production of megakaryocytes/platelets

cytokines

specifically animals with ______________ are often seen to have increased platelet production

iron deficiency anemia

a markedly high, persistent increase in thrombocytes with increased megakaryocytes in the bone marrow aspirate is called what

essential thrombocythemia