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what is the lymphatic system?
It is the vital, extensive network of tissues organs, and vessels that act as the body’s “sewerage” and defense system
what population of cells are found in the lymphatic system?
Cells:
Lymphocytes
T cells
B cells
Natural Killer Cells
Macrophages
Dendritic cells
Plasma cells
Lymphatic endothelial cells
Locations:
Lymph nodes
Spleen
Thymus
Bone marrow
Lymphatic vessels
What is the difference between lymphatic vessels, arteries, and veins?
Vessels:
Absorb the fluid between cells from lymph, transporting it through immune-filtering nodes before returning it to the blood
Thinnest walls, numerous valves, one-way flow
Arteries:
Transport oxygenated, nutrient-rich blood away from heart to tissues
Thick-walled, elastic, and muscular to withstand high pressure from heart, no valves
Veins:
Return deoxygenated blood, carrying waste products, back to heart
Thinner walls with a larger, irregular opening, valves to prevent back flow of blood
Name some organs associated with the lymphatic system
Lymph nodes, thymus, spleen, and bone marrow
What is lymph composed of?
Water
lymphocytes and leukocytes
proteins
fats
waste produces
electrolytes
In the respiratory system, what is the pathway from the nostrils to the alveoli?
Nasal cavity —> pharynx —> larynx —> trachea —> bronchi —> bronchioles —> alveoli
What type of epithelial tissue makes up the alveoli?
Simple squamous epithelium
What is the structure of the glottis?
opening between the vocal colds in the larynx
What is the structure of the Epiglottis?
leaf-shape flap of elastic cartilage located behind the tongue
What is the structure of the Trachea?
rigid tube starting below the larynx, often called the “windpipe,” composed of C-shaped cartilage rings
What is the structure of the Nasopharynx?
uppermost part of the pharynx, situated behind the nasal cavity
What is the structure of the Oropharynx?
middle part of the pharynx, located behind the oral cavity
What is the structure of the Larygnopharnx?
lowest part of pharynx, connecting larynx to esophagus
Definition of tidal volume (respiratory system)
volume of air moving in and out of lungs in a person at rest
Definition of Respiratory capacity (respiratory system)
the sum of two or more lung volumes
Definition of Ventilation rate (respiratory system)
the total volume of air moved in/out of the lungs per minute
Definition of Vital capacity (respiratory system)
maximum amount of air that can be expired after a forceful inspiration
Definition of Total lung volume (respiratory system)
the total volume of air in the lungs after taking the deepest breath possible
Definition of Hypoventilation (respiratory system)
insufficient breathing, blood has abnormally high PCO2
Definition of Hyperventilation (respiratory system)
excessive breathing, blood has abnormally low PCO2
If you are hyperventilating, why is it beneficial to breathe into a paper bag? What does this do to the oxygen and CO2 levels?
When you hyperventilate you have an excessive exhalation of carbon dioxide which makes your blood less acidic (increasing pH), so you breathe in a bag to which forces re-inhalation of carbon dioxide to increase you blood acidity back to normal (decreasing pH)
How does the body compensate at high elevation?
The body lowers oxygen levels by increasing breathing rate and heart rate (hyperventilation)
Is oxygen at a higher or lower partial pressure at high elevation?
Lower partial pressure
What is the normal partial pressure of oxygen at sea level?
160mmHG
What is the partial pressure of oxygen in the alveoli?
105mmHG
What is COPD?
Chronic obstructive pulmonary disease
Refers to any disorder that obstructs airflow on a long-term basis
Examples of COPD
asthma
emphysema
lung cancer
covid-19
explain asthma
Allergen triggers the release of histamine, causing intensive constriction of the bronchi and sometimes suffocation
explain Emphysema
Alveolar walls break down and the lung exhibits larger but fewer alveoli
Lungs become less elastic
People with emphysema become exhausted because they expand three to four times the normal amount of energy just to breathe
80-90% of emphysema deaths are caused by cigarette smoking
explain Lung cancer
Accounts for more deaths than any other form of cancer
Caused mainly by cigarette smoking
Lung cancer metabolizes (spreads) so rapidly that it has usually invaded other organs by the time it is diagnosed
Chance of recovery from metastasized lung cancer is poor, with only 3% of patients surviving for 5 years after diagnosis
explain covid-19
A novel coronavirus, manifests as a respiratory disease
Transmitted among people via respiratory droplets (coughing, sneezing, breathing, etc.)
Traced to a live animal marker in Wuhan City, China
A zoonotic disease (bats —> unknown animal —> humans), human consumption of or contract with an unknown infected animal
Bats have a strong immune response, probably linked to flying and the need to quickly repair cell damage
As a result, virus quickly adapts and replicates in bats
But bats don’t die and carry the virus far and wide
Infection in animal with weaker immune system (ex. Humans) means a highly virulent response
How do red blood cells get oxygenated?
Passive diffusion in the lungs where oxygen binds to hemoglobin and creates a oxyhemoglobin
How do red blood cells transport CO2?
Bicarbonate conversion, carbaminohemoglobin, and dissolved in plasma
What are the components of blood?
Plasma
red blood cells
white blood cells
platelets
Name all the plasma proteins and know their functions
Albumin = maintains colloid osmotic pressure (prevents edema), transports hormones, fatty acids, bilirubin, and drugs, and maintains blood volume
Globulins = alpha and beta globulins (transports lipids, ion, and fat-soluble vitamins) and gamma globulins (produced by B lymphocytes for immunity, identify and neutralize invaders like bacteria and viruses)
Fibrinogen = essential for blood coagulation, activated to form fibrin threads that create a sticky, fibrous mesh to stop bleeding
What are platelets, where are they made, and what is their function?
They are cell fragments that pinch off from larger cells in the bone marrow
Made in the bone marrow
Function in the formation of blood clots
how are turtles and humans respiratory system similar and different?
Similarities:
Both use lungs
Share similar basic anatomy including a trachea that splits into brooch leading to the lungs
Differences:
Humans use a diaphragm to expand lungs, turtles have a shell so they use inner muscles to move air
Turtles use “butt-breathing” during hibernation or long dives
Turtles can handle much higher carbon dioxide levels in their blood so they can hold their breath for hours
how are turtles and humans Digestive system similar and different?
Similarities:
Contains similar organs like esophagus, stomach, live, gallbladder, intestines, and functions similarly with bile produced in liver and stored in gallbladder
Differences:
Turtles have a cloaca for fecal, urine, and reproductive material, humans have separate openings
Turtles have a much slower digestion rate designed to break down plant cell walls via microbial digestion
Humans have teeth, turtles have a beak
how are turtles and humans circulatory system similar and different?
Similarities:
Both have a closed circulatory system with arteries and veins
Differences:
Humans have a 4-chambered heart, turtles have a 3-chambered heart
Humans have higher blood pressure and higher metabolism, turtles have lower blood pressure and lower metabolism
What are the stages of meiosis?
meiosis 1 and meiosis 2
explain meiosis 1
Prophase 1: chromosomes condense and pair up with their homologue, CROSSING OVER
Metaphase 1: homologous pairs align along the center of the cell, INDEPENDENT ASSORTMENT
Anaphase 1: homologous chromosomes are pulled to opposite poles of the cell, sister chromatids remain attached
Telophase 1 and Cytokinesis: chromosomes arrive at the poles and the cytoplasm divides into 2 haploid (n) cells
explain meiosis 2
Prophase 2: chromosomes condense and nuclear envelope breaks down again
Metaphase 2: chromosomes align in single file along the metaphase plate
Anaphase 2: sister chromatids separate and are pulled to opposite poles
Telophase 2 and Cytokinesis: nuclear membranes reform and the cytoplasm divides, resulting in 4 unique haploid daughter cells
How does meiosis increase genetic diversity?
Crossing over in prophase 1: homologous chromosomes pair up and exchange segments of DNA, creating new combinations of alleles (recombination)
Independent assortment in metaphase 1: homologous pairs align randomly along the cell equator, each gamete receives a unique mixture of maternal and paternal chromosomes
Does mitosis increase genetic diversity?
Mitosis does not increase genetic diversity
What are examples of adaptive evolution?
Peppered moths
Industrial melanism = phenomenon in which darker individuals come to predominate over lighter ones
Light-colored moths declined because of predation because they were easily seen by birds on darkened (sooty) trees
Darwin’s finches
Darwin collected a closely related group of 14 finch species in the Galapagos islands
All were similar except for break characteristics
Darwin hypothesized that different beak shapes were related to food gathering
Ancestral species adapted over time to equip to acquire different food sources
What are examples of coelomates?
process a true body cavity completely lined by mesoderm:
chordates (humans, birds, fish)
arthropods (insects, crustaceans)
mollusks (snails, clams)
annelids (earthworms)
echinoderms (starfish)
What are examples of acoelomates?
lack a body cavity entirely:
Platyhelminthes (flatworms, tapeworms, flukes)
cnidarians (jellyfish, corals)
What are examples of psuedocoelomates?
possess a “false” body cavity not completely lined by mesoderm:
nematodes (roundworms)
rotifers
What are the similarities and differences between an artery and vein?
Both have:
Endothelium, elastic layer, smooth muscle, and connective tissue
Transfer blood and in single directions
Differences:
Arteries carry blood away from the heart
Veins carry blood toward the heart
Arteries manage high-pressured blood flow
Veins operate at a lower pressure
Arteries have thicker walls, veins are thinner
Veins have one-way valves to prevent back flow of blood against gravity, arteries do not
Veins hold 65-75% of the body’s blood volume, arteries hold 15%
What is the function of a capillary?
Composed of only a single layer of endothelial cells
Allows for rapid exchange of gases and metabolites between blood and body cells
What is atherosclerosis?
Accumulation of fatty material within arteries
Impedes blood flow
What is arteriosclerosis?
Arterial hardening due to calcium deposition
What is a stent and angioplasty?
It is a minimally invasive procedure
Commonly called Percutaneous Coronary Intervention (PCI)
Used to open blocked coronary arteries and restore blood flow
Access: A doctor inserts a thin tube (catheter) into a blood vessel through the wrist or groin.
Visualization: Dye is injected to show the blockage using X-ray imaging.
Balloon Inflation: A tiny balloon is inflated at the site of the narrowing, pushing plaque against the artery wall.
Stent Placement: A small metal mesh scaffold (stent) is expanded by the balloon, remaining in place to keep the artery open.
what are the 4 valves of the heart?
Atrioventricular (AV) valves:
Maintain unidirectional blood flow between atria and ventricles
Tricuspid valve = on the right
Bicuspid (or mitral) valve = on the left
Semilunar valves:
Ensure one-way flow out of the ventricles to the arterial systems
Pulmonary valve = located at the exit of the right ventricle
Aortic valve = located at the exit of the left ventricle
Which side of the heart is high and low pressure?
High pressure = left side
Low pressure = right side
What is the job of the atria and ventricles?
Atria (upper chambers) = collect incoming blood to fill the ventricles
Ventricles (lower chambers) = contract strongly to pump blood out of the lungs and body
Both act as the heart’s receiving and pumping stations
Where does the systemic circulation go?
Moves blood between the heart and the rest of the body
Where does the pulmonary circulation go?
Moves blood between the heart and the lungs
Where is the apical and basal surface of epithelial tissue?
Basal = bottom/secured side
Apical = top/free side
What is the Hardy-Weinberg equation?
p^2 + 2pq + q^2 = 1
What does p and q signify?
p = dominant allele frequency
q = recessive allele frequency
What does p^2, 2pq, and q^2 signify?
p^2 = frequency of homozygous dominant alleles
2pq = frequency of heterozygous alleles
q^2 = frequency of homozygous recessive alleles
How do you calculate the frequency of heterozygous and homozygous recessive/dominant individuals?
Using Hardy-Weinberg!
What is endoderm, ectoderm, and mesoderm?
Ectoderm = outermost layer
Mesoderm = middle layer
Endoderm = innermost layer
What creatures have 2 germ layers?
Diploblasts like jellyfish, corals, sea anemones, comb jellies, etc. (cnidarians)
What creatures have 3 germ layers?
Triploblasts like humans, mammals, birds, fish, flatworms, mollusks, arthropods, etc. (chordata, mollusca, arthropoda, platyhelminthes)
Name an animal(s) for porifera:
sponges
Name an animal(s) for Cnidaria:
jellyfish, sea anemone, coral
Name an animal(s) for Ctenophora:
comb jellies
Name an animal(s) for Platyhelminthes:
flatworms, planaria, tapeworms
Name an animal(s) for Rotifera:
rotifers
Name an animal(s) for Nematoda:
roundworms
Name an animal(s) for Mollusca:
gastropoda, cephlapoda, bivalvia
Name an animal(s) for Annelida:
earthworms and leaches
Name an animal(s) for Arthropoda:
insects and crustaceans
Name an animal(s) for Echinodermata:
star fish and urchins
Name an animal(s) for Chordata:
humans, mammals, horses
what is type 1 diabetes?
“no key”
Usually develops in children or young adults, but can occur at any age
Pancreas does not produce insulin (hormone)
Must take daily insulin injections
what is type 2 diabetes?
“damaged lock”
Adult-onset, but can occur in adolescence
Often associated with obesity
Insulin rejection
Controlled through diet and exercise
What are side effects of having diabetes?
Cardiovascular disease
nerve damage
kidney damage
eye damage
foot complications
infections
mental health
What is the complete pathway of the digestive tract?
Mouth —> pharynx —> esophagus —> stomach —> small intestine —> large intestine —> rectum —> anus
What enzymes digest carbs, fats, and proteins?
Carbs = amylase
Lipase = fats
Pepsin or trypsin = protein
How are human GI tracts different from herbivores? Humans VS birds VS cows
Humans:
Mouth and pharynx = entry
Esophagus = delivers food to stomach
Stomach = preliminary digestion
Small intestine = digestion and absorption
Large intestine = absorption of water and minerals
Rectum = expel waste
Birds:
Lack teeth
Break up food in a two-chambered stomach
Gizzard = muscular chamber that uses ingested pebbles to pulverize food
Crop = storage
Cows:
They have a four-chambered stomach (rumen, reticulum, omasum, and abomasum)
Can ferment/digest tough cellulose
Rumination
They have a much longer tract
Evolved only once
Why do some animals eat their own feces?
Aka coprophagy
Eat their feces to absorb nutrients on the second passage of food
Cannot remain healthy if prevented from eating feces
What is cellulose?
A structural polysaccharide that forms the main component of plant cell walls providing rigidity and strength
What animals can digest it and can humans digest cellulose?
Ruminants like cows, sheep, goats
Hindmost fermenters like horses, rabbits
Humans cannot digest cellulose
What anatomical structures in the GI tract can digest cellulose?
Rumen (large, specialized chamber in the stomach where microorganisms ferment cellulose before it reaches the true stomach)
Cecum (found between small and large intestines and serves as main site for microbial breakdown of cellulose)
Colon/large intestine (further fermentation happens here)
Hindgut (insects)
What are all the epithelial tissues?
Simple squamous
Simple cuboidal
Simple columnar
Pseudostratified columnar
Stratified squamous
where is the simple squamous epithelial tissue found?
lines lungs and blood capillaries
where is the Simple cuboidal epithelial tissue found?
lines kidney tubules and several glands
where is the Simple columnar epithelial tissue found?
lines airways of respiratory tract and most of the gastrointestinal tract
where is the Pseudostratified columnar epithelial tissue found?
lining parts of respiratory tract (trachea, bronchi, and nasal cavity)
where is the Stratified squamous epithelial tissue found?
outer layer of skin, lining of mouth, keratinized
What is keratin and where is it found?
Keratin is a strong, fibrous protein produced naturally by the body that acts as the main structural support component of hair, skin, and nails
Found in outer layer of skin, hair, and nails
What are all the connective tissues?
Adipose
Dense regular
Dense irregular
Cartilage
Bone
Blood
where is the adipose connective tissue found?
subcutaneous layer under the skin
where is the dense regular connective tissue found?
tendons and ligaments
where is the dense irregular connective tissue found?
covers kidneys, muscles, nerves, and bones
where is the Cartilage connective tissue found?
joint surfaces
where is the Bone connective tissue found?
most of skeleton