MCAT Krebs/TCA Cycle

8 key players of Krebs Cycle

1. Citrate

2. Isocitrate

2. a-Ketoglutarate

4. Succinyl-CoA

5. Succinate

6. Fumarate

7. Malate

8. Oxaloacetate

Acronym for 8 key players

"Can I keep Selling Substances For Money, Officer?"

Acetyl-CoA has ____ carbons

Two

Oxaloacetate has ____ carbons

4

Citrate has ___ carbons

6 carbons

Krebs cycle is a _____ process that produces ____

oxidative process, produces energy

Carbon Counts of TCA cycle

Byproduct of Krebs cycle

CO2 (carbon dioxide)

Citrate synthase

acetyl CoA to citrate

Aconitase

citrate to isocitrate

isocitrate dehydrogenase

isocitrate to alpha-ketoglutarate

a-ketoglutarate dehydrogenase

a-ketoglutarate to succinyl-CoA

Succinyl-CoA synthetase

succinyl-CoA to succinate

Succinate dehydrogenase

succinate to fumarate

Fumarase

fumarate to malate

Main products of Krebs cycle

NADH and FADH2

NADH production takes place at every ___

carbon drops (NAD+ reductions)

-6C isocitrate to 5C a-ketoglutarate

-5C a-ketoglutarate to 4C succinyl-CoA

-facilitated by dehydrogenase enzymes

Which is the ONLY enzyme that requires energy in TCA cycle?

succinyl-CoA synthetase (GDP + Pi --> CoA-SH + GTP)

Malate dehydrogenase

malate to oxaloacetate