Cell Biology - Transport from the TGN to the Cell Exterior & Endosomes

These flashcards cover key concepts related to protein sorting and transport mechanisms in cell biology as discussed in the lecture.

Trans Golgi Network (TGN)

A central hub in the cell where proteins are sorted for transport to their final destinations.

M6P signal

A signal that directs lysosomal hydrolases from the TGN towards endosomal/lysosomal compartments.

Inclusion Cell Disease

A lysosomal storage disorder caused by a loss of the M6P signal, leading to accumulation of biomolecules in lysosomes.

Dense Core Secretory Vesicles (DCVs)

Vesicles that assemble cargo into large aggregates for secretion from the trans-Golgi.

Granins

Proteins that assist in the aggregation and sorting of cargo into dense core secretory vesicles.

V-type ATPase

An enzyme that acidifies the lumen of synaptic vesicles for loading of neurotransmitters.

Calcium signaling

The process that triggers vesicle fusion with the plasma membrane, important for neurotransmitter release.

Synaptic Vesicles (SVs)

Vesicles that store neurotransmitters and are involved in neurotransmission at nerve terminals.

Sorting receptors

Proteins that help mediate the sorting of cargo into specific vesicles during transport.

Apical and basolateral domains

Different regions of polarized cells that require regulated delivery of membrane proteins.