Random Facts

When to use  chi-square, ANOVA, student t-test, Mann-Whitney, Wilcoxon.

Cohort vs Case Controlled

Cohort studies begin with an exposure and look forward (or historically backward) to see if an outcome develops. Case-control studies begin with an outcome and look backward to find the exposure

Interpertation of RR vs RRR vs ARR

RR: “X% as likely”

RRR: X% less likely”

ARR: “X% benefit from treatment” or “For every 100 patients treated, X fewer will have an event”

Alpha and error types

Alpha is preset by investigators to dictate an acceptable probability of false positive results (ie, type I error).

Type 2 error depends on Beta

Converting from NPH to glargine

Decrease by 20%

Converting from Toujeo to other glargines

Decrease by 20%

mOsm equation

Mosm/L= (g/l sub / MW) x #particles x 1000

clearance equation

bioavailability equation

100 x AUCex/AUCintra x Doseintra/Doseextra

Start with A and E then cross

Vd

Amount drug in body/concentration drug in plasma

Clearance

F x Dose /AUC

Ke =

Cl/Vd

ln (C1/C2)/t

Steroid conversions

Cortisone 25

hydrocort 20

Pred 5

Prednisolone 5

Methylpred 4

Triamcinalone 4

Dex 0.75

Beta 0.6

Statin conversions

Rosuva 5
Atorva 10
Simva 20
Lova 40

Prava 40

Fuva 80

Yellow vs Black vs Red waste bins

🟡 Yellow = trace chemo

⚫ Black = bulk hazardous drug waste

🔴 Red = infectious/biohazard waste 

How to sterilize heat sensitive drugs

Use filtration (0.22 micron filter)

What drugs need filters

GAL Is PAT who has a MAP

Golimumab

Amphetericin B lipid

Lipids 1.2 micron

Isavacunazonium

Phenytoin

Amio

Taxanes

Mannitol20% or more

Drug to protect from light

Phytonadione (Vit K)

Epoprotenol

Nitrprusside

Micafungin

Doxycycline

Protect Every Necessary Med from Daylight

Drug recall classes: Class I, II, III

Class I = death/serious harm
Class II = temporary/reversible harm
Class III = not likely to harm

TSH/T4 normal values

T4: 0.9-2.3

TSH: 0.3-3

Digoxin drug interactions

PGP and 3A4 substrate

Increased levels with amio, dronedarone, dilt, verapamil

Must decrease dose by 50% with amio and dronedarone

What drugs increase INR with warfarin

azole antifungals

capcetiabine

cimetidine

bactrim

metronidazole

fluvastatin

When starting amio decrease warfarin dose

Avoid use with tamoxifen

What drugs decrease INR with warfarin

Phenytoin

Carbamazepine

Pehnobarb

rifampin

St Johns wort

Converting between warfarin and DOACS

R <3
E <= 2.5
A <2
D <2

What drugs increase lithium

ACEi, ARBs, Thiazides

NSAIDs

Risk of seratonin syndrome

Neurotoxicity with veramapil, dilt, carbamazepine or phyentoin

what is PSA

Prostate

DILE

Methimizole

PTU

Methyldopa

Minocycline

Procainamide

Hydralazine

Anti TNFs

Terbinafine

Isonaized

Quinidine