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Cystic Kidney Disease primary cilum
mechanoreceptor that senses urine flow and is linked to regulatory responses, including a Ca channel
ARPKD (autosomal-recessive polycystic kidney disease)
neonatal period, kidneys are uniformly enlarged, CDs are enlarged from the medulla to the cortex, liver is commonly cystic along w kidneys
ADPKD (autosomal dominat polycystic kidney disease
adulthood, PKD1 on chromosome 16 or PKD2 on chromosome 4, inevitability of renal failure means dialysis or transplation
Clear cell carcinoma
VHL gene, loss of function allows for excessive growth stimulation originating in the cortex from cells in the PCT
Papillary carcinoma
MET gene, codes for growth factor receptos