Activation of Tyrosine Kinase Receptors (Topic 6)

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Last updated 4:32 PM on 4/11/26
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4 Terms

1
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1.

Ligand binding

  • causes receptor dimerization

<p>Ligand binding</p><ul><li><p>causes receptor dimerization</p></li></ul><p></p>
2
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2.

Receptor subunits associate

  • they “cross phosphorylate” the tyrosine residues

  • auto phosphorylation

<p>Receptor subunits associate</p><ul><li><p>they “cross phosphorylate” the tyrosine residues</p></li><li><p>auto phosphorylation</p></li></ul><p></p>
3
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3.

Phosphorylated receptors are “activated”

  • the receptor recruits or binds to proteins through its phosphorylated tyrosines

<p>Phosphorylated receptors are “activated”</p><ul><li><p>the receptor recruits or binds to proteins through its phosphorylated tyrosines</p></li></ul><p></p>
4
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4.

SH2 and PTB domains of specific intracellular proteins

  • recognize and bind to the phosphorylated tyrosines on the receptor (using their SH2 domains)

  • the receptor may also in turn phosphorylate and activate the recruited proteins

Pathways are turned on depending on recruited SH2 domain proteins

<p>SH2 and PTB domains of specific intracellular proteins</p><ul><li><p>recognize and bind to the phosphorylated tyrosines on the receptor (using their SH2 domains)</p></li><li><p>the receptor may also in turn phosphorylate and activate the recruited proteins</p></li></ul><p>Pathways are turned on depending on recruited SH2 domain proteins</p>