Bio - pyruvate oxidation (stage 2)

What is pyruvate oxidation known as

Linking reaction

Why is it both technically 1 step reaction and 3 step reaction

1 - because its all being done by 1 enzyme reaction
3 - Split into 3 parts to be more specific

Where does it start and where does it happen

Start - Cytoplasm (from glycolysis)
Occurs - mitochondrial matrix

How does pyruvate enter mitrochondria

Facilitated diffusion, enters through a transport protein

What are the 3 key reactions and explain

Decarboxylation - CO2 is removed and released as waste (carboxyl group)
Oxidation - NAD+ takes 2 H and becomes NADH
Formation of acetyl-CoA - 2 carbon molecule attaches to coenzyme A and form acetyl CoA

What is acetyl group

CH3-C-_O

Coenzyme A

Large molecule with a sulfur atom
Temporarily bonded to pyruvate through weak bond

Location of products after reaction

Acetyl-CoA - Undergoes kerb cycle
CO2 - exhaled out
H+ - released into the mitrochondrial matrix
NADH - Goes to ETC

What is the final product in pyruvate oxidation

Acetyl-CoA