10.3 Sarcomere: Crossbridge Cycling

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3rd physiologic event in skeletal muscle contraction

Last updated 12:24 AM on 4/3/26
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5 Terms

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3a Ca2+ binding

  • Ca binds to troponin in muscle thin filaments

  • troponin changes shape & entire troponin-tropomyosin complex

  • tropomyosin doesn’t cover myosin binding site on actin anymore

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3b Crossbridge formation (“attach”)

  • myosin heads bind to the exposed myosin binding site on actin

  • forms crossbridge between myosin & actin

3
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3c power stroke (“pull”)

  • myosin head goes towards center of sarcomere & pulls along attached thin filament

  • movement is called power stroke

  • ADP & P are released

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3d release of myosin head (“release”)

  • ATP binds to ATP binding site on myosin

  • causes release of myosin head from binding site on actin

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3e reset myosin head (“reset”)

  • ATP is split into ADP & P by myosin ATPase

  • provides energy to reset the myosin head