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1/3
More than ___ of adults in the US have some form of heart & blood vessel disease
15-20
Sudden cardiac death & arrhythmia account for _-_% of all deaths
Cardiovascular disease
Array of conditions that affect the heart & blood vessels
Heart disease
Leading cause of death for men, women, & people of most racial & ethnic groups
Stroke
Condition in which the blood supply to part of the brain is blocked or ruptures, resulting in severely restricted blood flow that deprives brain tissue of oxygen & nutrients
Peripheral vascular disease
Narrowing of the peripheral blood vessels; driven by atherosclerosis, leading to macro & microvascular dysfunction
Peripheral arterial disease
Chronic progressive atherosclerotic disease leading to partial or total peripheral vascular occlusion
Coronary heart disease / CHD
Condition in which the arteries that supply the heart muscle with oxygen & nutrients are narrowed by fatty deposits, such as cholesterol & triglycerides
Coronary heart disease
Most common form and leading cause of death of cardiovascular disease
Angioplasty
Procedure where a balloon-tipped catheter is inserted & inflated to widen the inner lumen of the artery
Electrocardiogram
Measures the heart’s function & is a recording of the electrical activity of the heart
Stress Electrocardiogram
Graded exercise stress test where the workload is increased gradually until the individual reaches maximal fatigue, with BP & 12-lead EKG monitoring throughout test
Recovery ECG
Monitors return of the heart’s activity to normal conditions
Cholesterol
Waxy substance found in animal fats & oil; used in making cell membranes, as building blocks for some hormones, fatty sheath around nerve fibers, & other substances
Triglycerides
Fats formed by glycerol & three fatty acids; also called free fatty acids
Blood lipids
Consist of cholesterol & triglycerides
HDL
Help clear cholesterol from the blood; “good” cholesterol
LDL
Tends to increase blood cholesterol by releasing it, leading to plaque formation in arteries; “bad” cholesterol
VLDL
Triglyceride, cholesterol, and phospholipid-transporting molecules in the blood
Chylomicrons
Triglyceride-transporting molecules
Atherosclerosis
Fatty or cholesterol deposits in the walls of arteries, leading to formation of plaque
Myocardial infarction
Damage to or death of an area of the heart muscle as a result of an obstructed artery; heart attack
Angina pectoris
Chest pain
75
Typical symptoms of heart disease do not start until arteries are about __% blocked
Reverse cholesterol transport
HDL molecules help prevent plaque from forming in the arteries by attaching to cholesterol & carrying it to the liver where it is changed to bile & eventually excreted into the stool
<200
Desirable total cholesterol level
<100
Optimal LDL cholesterol level
>/= 60
High HDL cholesterol level (optimal)
400-600 mg
The average adult in the US eats about ___ of dietary cholesterol per day
Saturated fats
Found in mostly meats & dairy products
Trans fats
Found in fried foods, margarine, & baked goods (crackers, biscuits, pies)
Unsaturated fats
Mainly of plant origin & cannot be converted to cholesterol
<1%
American Heart Association dietary guidelines recommend limiting trans fat intake to __ of total daily caloric intake
25-38g
Total daily intake of fiber to lower LDL cholesterol
25-35
Percent fat of total daily caloric intake to lower LDL cholesterol
7
Number of servings of fruits & vegetables per day to lower LDL cholesterol
Soluble fiber
Dissolves in water & forms a gel-like substance that encloses food particles; binds to fat & bile acids and excretes them from the body; shown to lower LDL cholesterol
Poly & monounsaturated fats
Typically liquid at room temperature; in fish, nuts, seeds, vegetable oils
Triglycerides
Make up most of the fat in our diet & most of the fat circulating in the blood
<150
Desirable level of triglycerides
140; 35
LDL phenotype B have triglyceride levels above ___ & HDL levels below ___
Homocysteine
Amino acid that builds proteins & carry out cellular metabolism; is metabolized quickly; may lead to plaque formation & blocked arteries when accumulated into blood
C reactive protein
Levels measured to assess for ongoing inflammation
C reactive protein
Protein produced in the liver whose blood levels increase with injury or irritation anywhere in the body
Plac blood test
Measures level of lipo-protein-associated phospholipids A2 & indicates risk of plaque rupture
Phospholipase A2
An enzyme produced inside a plaque when the arteries are inflamed
Metabolic syndrome
Array of metabolic abnormalities that contribute to development of atherosclerosis triggered by insulin resistance
1/5
About ___ of adult population is affected by metabolic syndrome
Blood pressure
The measure of the force exerted against the walls of blood vessels by the blood flowing through them; measured in mmHG
Systolic
Pressure exerted against walls of arteries during forceful contraction of heart
Diastolic
Pressure exerted against walls of arteries during relaxation phase of the heart
120/80 or lower
Ideal blood pressure
Hypertension
Chronically elevated blood pressure
1/3
Approx. ___ adults are hypertensive
20/10
CVD risk doubles with each BP increase of ___
10
Percentage of hypertension caused by pathological conditions
90
Percentage of hypertension that has no definite cause; “essential hypertension”
Moderate 150 min/week; 40-60% HRR
Aerobic exercise recommendation for adults with hypertension
12-15 reps of somewhat hard; 8-10 multi-joint exercises 2-3 days/week
Strength training recommendation for individuals with hypertension
Tobacco use/smoking
Single largest preventable cause of illness & premature death in US
20
Approx. __% of all deaths from CVD are attributed to smoking
Catecholamines
Body responds to stress by producing:
Epinephrine, norepinephrine
“Fight or flight” hormones that increase heart rate, blood pressure, and blood glucose levels to enable a person to take action
55
Genetic predisposition for premature CHD age for heart attack in males
65
Genetic predisposition for premature CHD age for heart attack in females
40 or higher
HDL cholesterol level to lower risk of CVD & cardiac events
<100
LDL cholesterol level to lower risk of CVD & cardiac events
Stress
Body’s mental, emotional, and physiological response to any new, threatening, frightening, or exciting situation; prepares the organism to react to the event
Immunity
The function that guards the body from invaders, both internal & external
Immune system
Patrols & guards the body against attackers; involves lymphocytes, antibodies, & immune system cells in the thymus gland, spleen, bone marrow, & lymph nodes
8
Most people require about __ hours of sleep
Eustress
Positive stress; health & performance continue to improve even as stress increases
Distress
Negative stress; unpleasant or harmful stress under which health & performance begin to deteriorate
General adaptation syndrome
The body’s adaptation to sustained stress
Alarm reaction, resistance, exhaustion/recovery
Three steps of stress adaptation
Alarm reaction
Immediate response to the stressor
Resistance
If stressor persists, the body copes effectively and meets the challenge of the stressor until it can be overcome
Exhaustion/recovery
Body drains reserves as it continues to resist stress; the body functions at diminished capacity until through a recovery period
Explanatory style
The manner people use to explain things that happen to them
Pessimism
Negative interpretation of events; can delay healing time & worsen course of illness
Optimism
Positively interprets events; increases strength of immunity
Self esteem
How you view and assess yourself
High self esteem
Feeling good about one’s capabilities; boosts immune system & aids healing
Low self-esteem
Influences whether and for how long people get sick; worsens chronic pain
Type A
Hard-driving, overambitious, aggressive, at times hostile, overly competitive
Type B
Calm, casual, relaxed, easy-going
Type C
As highly stressed as Type A, but not at higher risk for disease than Type B
Health, social support, self-worth, nurturance
Factors influencing vulnerability
Technostress
Tech-related stress resulting form inability to cope with technology in a healthy way
Fight or flight
Physiological response of the body to stress that prepares the individual to take action by stimulating the body’s vital defense systems
Yoga
Seeks to help the individual attain a higher level of spirituality and peace of mind
Tai chi
Promotes serenity through gentle, balanced, low-impact movements bringing together the mind, body, & emotions
Endorphins
Morphine-like substances released from the pituitary gland during prolonged aerobic exercise
Progressive muscle relaxation
Stress management technique that involves sequential contraction & relaxation of muscle groups through the body; helps person become more alert to signs of distress
Visual imagery
Mental visualization of relaxing images to induce body relaxation in times of stress or as an aid in the treatment of certain medical conditions
Autogenic training
A form of self-suggestion; individual places themself in autohypnotic state by repeating and concentrating on feelings of heaviness and warmth in the extremities
Meditation
Stress management technique used to gain control over one’s attention by clearing the mind & blocking out stressors responsible for increased tension
Hatha yoga
Incorporates specific sequences of static stretching postures to help induce relaxation response