Microcytic anemia

What type of anemia is caused by deficient intake, defective absorption, or excess loss of iron?

IDA

Which anemia shows microcytosis and hypochromia with pencil cells?

IDA

In iron deficiency anemia, what happens to serum iron?

Decreases

In iron deficiency anemia, what happens to TIBC?

Increases

In iron deficiency anemia, what happens to iron saturation?

Decreases

In iron deficiency anemia, what happens to ferritin?

Decreases

In iron deficiency anemia, what happens to soluble transferrin receptor?

Increases

In iron deficiency anemia, what happens to zinc protoporphyrin?

Increases

Which marrow change is listed in iron deficiency anemia?

Erythroid hyperplasia

What storage finding is decreased in iron deficiency anemia?

Iron stores

Which microcytic anemia commonly shows microcytosis?

IDA

Which microcytic anemia commonly shows hypochromia?

IDA

Which microcytic anemia commonly shows anisocytosis?

IDA

Which microcytic anemia commonly shows poikilocytosis?

IDA

Which microcytic anemia commonly shows thrombocytosis?

IDA

Which microcytic anemia commonly shows pencil cells?

IDA

Which microcytic anemia commonly shows elliptocytes?

IDA

Which microcytic anemia commonly shows target cells?

IDA

What type of globin production problem defines thalassemia?

Quantitative

Which infection belt does thalassemia incidence parallel?

Malaria

Decreased alpha-chain production forms what general structure?

Tetramers

One alpha-gene deletion is called what alpha-thalassemia state?

Silent carrier

Two alpha-gene deletions are called what alpha-thalassemia state?

Minor

Three alpha-gene deletions cause which disease?

HbH disease

Four alpha-gene deletions cause which condition?

Hydrops fetalis

Hemoglobin H is made of which chains?

β4

Bart's hemoglobin is made of which chains?

γ4

Decreased beta-chain production increases which hemoglobins?

A2/F

Homozygous beta thalassemia is also called what?

Cooley anemia

Heterozygous beta thalassemia usually causes what anemia severity?

Variable

Which microcytic genetic anemia is associated with increased RBC count?

Thalassemia

Which microcytic genetic anemia is associated with low MCV?

Thalassemia

Which microcytic genetic anemia is associated with low hematocrit?

Thalassemia

Which microcytic genetic anemia is associated with low hemoglobin?

Thalassemia

Which microcytic genetic anemia is associated with nucleated RBCs?

Thalassemia

Which microcytic genetic anemia is associated with basophilic stippling?

Thalassemia

Which microcytic genetic anemia is associated with polychromasia?

Thalassemia

Which microcytic genetic anemia is associated with target cells?

Thalassemia

Which microcytic genetic anemia is associated with splenomegaly?

Thalassemia

Which microcytic genetic anemia is associated with hypersplenism?

Thalassemia

Which microcytic genetic anemia is associated with iron overload?

Thalassemia

What MCV range is listed for beta thalassemia?

55-65 fL

What MCV range is listed for alpha thalassemia?

65-67 fL

Which anemia results from an enzymatic defect in heme synthesis?

Sideroblastic

Where does excess iron accumulate in sideroblastic anemia?

Mitochondria

Which inherited form is listed for sideroblastic anemia?

X-linked

Which toxin produces findings similar to sideroblastic anemia?

Lead

Which enzyme pathway is inhibited by lead in the notes?

ALA synthase

Which marrow finding is increased in sideroblastic anemia?

Ring sideroblasts

In sideroblastic anemia, what happens to serum iron?

Increases

In sideroblastic anemia, what happens to TIBC?

Decreases

In sideroblastic anemia, what happens to iron saturation?

Increases

In sideroblastic anemia, what happens to ferritin?

Increases

Which acquired microcytic anemia can be caused by myelodysplasia?

Sideroblastic

Which acquired microcytic anemia can be caused by medication?

Sideroblastic

Which acquired microcytic anemia can be caused by alcohol abuse?

Sideroblastic

Which acquired microcytic anemia can be caused by irradiation?

Sideroblastic

Which acquired microcytic anemia can be caused by copper deficiency?

Sideroblastic

Which anemia is associated with hypochromic RBCs?

Sideroblastic

Which anemia is associated with dimorphic RBCs?

Sideroblastic

Which anemia is associated with basophilic stippling?

Sideroblastic

Which anemia is associated with Pappenheimer bodies?

Sideroblastic

Which anemia is associated with macrocytosis?

Sideroblastic

Which anemia is mediated by hepcidin as an acute phase reactant?

Chronic inflammation

In chronic inflammation anemia, what happens to reticulocyte count?

Decreases

In chronic inflammation anemia, what happens to iron stores?

Increase

In chronic inflammation anemia, what happens to serum iron?

Normal/decreased

In chronic inflammation anemia, what happens to TIBC?

Normal/decreased

In chronic inflammation anemia, what is the iron saturation clue?

15%

In chronic inflammation anemia, what happens to ferritin?

Normal/increased

In chronic inflammation anemia, what happens to SSTR?

Normal