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What features are not present in smooth muscle?
Tranverse tubules and striations
Muscle fibers generally have only one motor end plate, but a single motor neuron can innervate many different muscle fibers in a group. How does this arrangement affect muscle contraction?
A signal from one motor neuron can potentially stimulate multiple fibers in a group to contract, generating more force.
Where is the location of the vesicles containing neurotransmitter molecules?
At distal end of motor axon
What type of muscle fiber is large in diameter and contains abundant glycogen and relatively few mitochondria?
Fast glycolytic fiber
After finishing a sprint, a runner experienced painful cramps in their calf muscles. A deficit in which molecule would explain the cramping?
ATP
Which of these options lists the structures in order, from deepest to most superficial?
Endomysium, perimysium, epimysium, fascia
What is a function of transverse tubules?
To transmit action potentials (impulses) into the cell interior
A runner collapses during their 800-meter race. A medical exam finds that they have lost the ability to plantar flex at the ankle. What muscle has most likely been injured?
Gastrocnemius
As a muscle fiber is stimulated with increasing frequency, individual twitches begin to summate. If no relaxation occurs between twitches, the contraction is called __________
fused tetany
What muscle originates at the transverse processes of the cervical vertebrae and inserts at the medial border of the scapula?
Levator scapulae
What change occurs with aging?
Decreased supply of myoglobin
True or False: Endomysium separates individual muscle fibers from each other.
True
During a muscle contraction, why is ATP required?
To allow myofilament movement
What is the location of the buccinator muscle?
Cheek
Why does oxygen debt develop?
The respiratory and circulatory systems are unable to supply enough oxygen for skeletal muscles to work strenuously for a minute or two.
In a laboratory that studies muscle function, a group of rats are bred that, due to a genetic defect, produce a non-functional version of troponin. As a result, the rats are paralyzed. What explains the impact of this defect on muscle?
Troponin can’t bind calcium ions and, thus, will not change shape nor cause tropomyosin to move away from the binding sites on the thin filament.
Which of the following is unique in that its insertion is onto fascia and not bone?
palmaris longus
What happens in a muscle as it undergoes atrophy in response to disuse?
The size of actin and myosin filaments decreases.
True or False: A motor neuron and the muscle fibers that it innervates form a motor unit.
True
Why are athletes typically able to exercise longer before developing muscle fatigue than non-athletes?
Due to training, athletes have a better blood supply and more mitochondria in their muscles than do non-athletes.
What muscle causes movement at the temporomandibular joint (TMJ)?
masseter
Curare is a poison that binds to acetycholine receptors at the motor end plate. What is the result of curare poisoning?
Inability of the muscle fiber to respond to nervous stimulation
What is the main component of thin filaments?
Actin
What neurotransmitter(s) can stimulate smooth muscle cells?
Both norepinephrine and acetylcholine
Since the action of the rectus femoris and the biceps femoris muscles oppose each other at the knee, functionally these muscles can be described as __________ to each other.
antagonists
The soleus muscle forms part of the __________
calf
During walking, the gastrocnemius muscle (calf muscle) contracts, shortening and causing plantar flexion. This type of muscle contraction is called a(n) __________ contraction.
concentric
Regina began an exercise program six months ago, and the muscles of her upper limbs and lower limbs have become more prominent. How does exercise lead to formation of new muscle?
By stimulating muscle cells to release IL-6, which stimulates satellite cells to divide
The origin of the occipitalis muscle is the __________ bone of the skull.
occipital
Consider a muscle that originates on the posterior femur and inserts on the posterior tibia. What is the action of this muscle?
To flex the knee
The amount of oxygen that liver cells require to support the conversion of lactic acid to glucose or glycogen is called the __________
oxygen debt
What is the function of acetylecholinesterase?
To break down acetylcholine
Which connective tissue layer is comprised of loose connective tissue?
endomysium
What term describes the more movable end of a muscle?
Insertion
Which of these events occurs first in muscle fiber contraction?
Acetylcholine is released from the axon of the motor neuron
What is the linea alba?
A band of tough connective tissue on the midline of the abdomen
What term describes a muscle that opposes a particular action?
Antagonist
How do skeletal muscles help maintain body temperature?
Muscle contraction releases heat.
What binds to the exposed cross-bridges on actin?
Myosin
A broad sheet of dense connective tissue that attaches a muscle to bone, skin, or other muscles is called a(n) __________
aponeurosis
Bones and muscles function together as mechanical devices called __________
levers
Arrange the steps of muscle fiber contraction in the correct order:
The muscle impulse reaches the sarcoplasmic reticulum and calcium is released.
Thin filaments are pulled over the thick filaments.
Calcium floods the sarcoplasm and binds to troponin molecules leaving active sites.
The impulse arrives at the synapse and travels through the transverse tubules.
The muscle fiber shortens and contracts.
Myosin heads bind to exposed active sites on actin, forming cross-bridges.
4, 1, 3, 6, 2, 5
Following stenuous exercise, levels of ATP, creatine phosphate, oxygen, and glucose must be returned to normal levels. This situation, called __________ may take several hours to complete.
Oxygen debt
What are fascicles?
Bundles of muscle fibers
What term refers to an increase in the number of motor units activated as a result of more intense stimulation?
Recruitment
Which of the following is the functional connection between a neuron and a skeletal muscle fiber?
Synapse
The pigment responsible for the reddish brown color of skeletal muscle is __________
myoglobin
In a laboratory that studies muscle function, a group of rats are bred that, due to a genetic defect, have myosin heads which bind ADP irreversibly. As a result, the rats are paralyzed. What explains the impact of this defect on muscle?
Because ADP is permanently bound, the myosin heads will be irreversibly cross-bridged with the actin binding sites on the thin filament.
What is the cause of rigor mortis that occurs in skeletal muscles a few hours after death?
A decrease in ATP and increased membrane permeability to calcium.
The structures that anchor cardiac muscle cells to each other are called __________
intercalated discs
Many muscles are named for their location in the body, particularly in relation to bones. In what body region would you expect to find the frontalis muscle?
The cranial region
What is the functional unit of muscle contraction?
Sarcomere
True or False: Acetylcholine released by a myofibril crosses the synaptic cleft to bind to the motor end plate.
False
A forceful, sustained muscle contraction is called a(n) __________ contraction.
tetanus
What enzyme degrades acetylcholine, keeping it from accumulating in the synapse?
Acetylcholinesterase
Instead of using troponin to bind calcium ions, smooth muscle cells use __________
calmodulin
How does smooth muscle compare to skeletal muscle?
Smooth muscle contracts more slowly and relaxes more slowly.
Name the area of the sarcolemma that is part of a neuromuscular junction.
Motor end plate
In producing a movement, the muscle that causes an action is acting as the __________
agonist
What is a threshold stimulus?
Minimum stimulus strength required to contract a muscle fiber
Accumulation of lactic acid or depletion of ATP, most likely causes muscle __________
fatigue
What occurs during excitation-contraction coupling?
SR cisternae release calcium ions into the cytosol
Myofibrils are composed primarily of __________
actin and myosin
True or False: ATP is necessary for muscle relaxation.
True
During the motion that extends the upper limb at the elbow, the elbow joint represents which part of the lever?
Fulcrum
True or False: Recruitment refers to increasing the number of motor units involved in a muscle contraction.
True
When acetylcholine binds to its receptors at the motor end plate, the muscle fiber membrane becomes more permeable to __________
sodium
In a recording of a muscle twitch, a delay occurs between the time a stimulus is applied and the time the muscle responds. What is this delay called?
Latent period
Muscles that assist an agonist are acting as __________
synergists
Since the action of the rectus femoris and the vastus lateralis muscles produce the same action at the knee, functionally these muscles can be described as __________ to each other.
synergists
What makes up the cross-bridges that form during a contraction?
Myosin heads binding to actin
A tendon is __________, whereas an aponeurosis is __________.
cordlike and connects muscles to bones; a broad sheet of dense connective tissue that connects muscles to muscles
Which statement describes a sarcomere?
A segment of a muscle fiber
Since many muscles are named for their location, it can be assumed that the zygomaticus muscles originate on the __________ bones of the skull.
zygomatic
What makes up muscle fibers?
sarcomeres
As a worker carries a heavy box, their arm muscles contract, but the box doesn't shift its position. The arm muscles are undergoing __________ contractions.
isometric
True or False: The myosin heads function as ATPase enzymes.
True
Botulism results from ingestion of a toxin produced by a type of bacterium. Along with other symptoms, it causes a type of paralysis in which the muscles cannot contract. Why does this paralysis occur?
The toxin prevents release of acetylcholine.
In a muscle twitch, the period of time during which the force of contraction is increasing is the ___________ period.
contraction
True or False: During cross-bridge cycling, calcium ions bind to tropomyosin, exposing active sites on actin for cross-bridge formation.
False
What is an example of a partial but sustained contraction?
Muscle tone
Certain natural plant poisons and animal venoms contain substances that inhibit the function of acetylcholinesterase. If a person is poisoned by one of these substances, which of the following will be the cause of their symptoms?
Muscles will be in a constant state of contraction because acetylcholine won't be broken down and cleared from the neuromuscular junction.
What characteristics would be found in the muscle fibers stimulated during activities such as distance swimming and distance running?
Slow contracting and fatigue-resistant
A muscle that will adduct the thigh (moving it toward the midline of the body) will be located in what area?
Inner thigh
Consider a muscle that originates on the anterior forearm and inserts on the palm of the hand. What is the action of this muscle?
To flex the wrist
What muscle originates on the proximal tibia, inserts on the foot, and causes dorsiflexion and inversion of the foot.
Tibialis anterior
How do slow-twitch fibers (type I) compare to fast-twitch fibers (type IIb)?
Type I fibers have more mitochondria than type IIb fibers.
A muscular contraction in which the muscle shortens, moving an object, is called a(n) __________ contraction.
concentric
The triangle of auscultation, commonly used to hear sounds of respiratory organs, is bounded by what muscles?
Trapezius, rhomboid major, and latissimus dorsi
What is the function of creatine phosphate?
In many movements, the agonist is assisted by other muscles. A muscle that assists the agonist is called a(n) __________
syngerist
What causes the striated appearance of skeletal muscle fibers?
Organization of components of the sarcomeres
What muscle cells are short in length and have centrally located nuclei?
Smooth muscle cells
The rectus femoris originates on the ___________ and inserts on the ___________.
anterior superior iliac spine; tibial tuberosity
Increased frequency of stimulation results in the combining of a series of twitches to produce a more forceful contraction in a process called __________
summation
What structures connect cardiac muscle cells together?
Intercalated discs
The rhythmic, wavelike motion produced by smooth muscles in tubular organs is called __________
peristalsis
In skeletal muscle fibers, what is the source of the calcium ions that are released into the sarcoplasm to bind with troponin, resulting in contraction?
Sarcoplasmic reticulum
During strenuous exercise, when muscles are not being supplied with enough oxygen, a shift in metabolism results in the breakdown of pyruvic acid to lactic acid. What is this change in metabolism called?
Lactic acid threshold
The characteristic reddish brown color of skeletal muscle is due to the presence of which substance?
myoglobin