TOP 300- INTERACTIONS

amoxicillin interactions

1) Methotrexate- avoid

2) Warfarin- increase monitoring

3) Typhoid vaccine- avoid

4) Sodium picosulfate- use alternative

5) Allopurinol- educate and monitor

augmentin interactions

1) Methotrexate- avoid

2) Warfarin- increase monitoring

3) Typhoid vaccine- avoid

4) Sodium picosulfate- use alternative

5) Allopurinol- educate and monitor

Atazanavir interactions

1) CYP 3A4/5 inhibitors, substrates and inducers- avoid

2) antacids: seperate 2h

3) Drugs that prolong pr or qtc interval- avoid or monitor

4) Oral contraceptives- use alternative

5) PPI and H2RA- avoid PPi and H2RA seperate by 2h

6) UGT1A1 substrate- avoid

azithromycin interactions

1) Agents that prlong qtc interval and c3 arythmatics- avoid

2) Statins-avoid

3) Digoxin-avoid

4) Ergot alkaloids- avoid

5) Nefinavir- caution

6) Warfarin- monitor INR closely

7) Typhoid vaccine- avoid

8) Sodium picosulfate- use alternative

cefdinir interactions

1) Al/Mg containing irons vit or antacids- seperate by 2h

2) Aminoglycosides- avoid

3) Typhoid vaccine-avoid

4) sodium picosulfate- alternative

5) Vit k antagonist- monitor

cefuroxime interactions

1) Estrogen based BC- alternative

2) typhoid vaccine- avoid

3) Sodium picosulfate- alternative

4) Antacids- 2h PPI and H2RA- avoid

5) Vit k antagonist- monitor

cephalexin interactions

1) BCG vac- monitor

2) Typhoid vac- consider modification

3) cholera- avoid

4) multivit and minerals- consider stopping

5) sodium pico- alternative

6) metformin- increase monitoring

7) cholestyramine- administer cephalexin 1h before or 6h after

chlorhexidine interactions

None

ciprofloxacin otic interactions

None

ciprofloxacin PO interactions

1) diabetic agents- avoid

2) Al Ca and Mg containing- take cipro 2h before or 6h after

3) corticosteroids- discontinure cipro

4) CYP1A2 sub- monitor or avoid

5) warfarin- inc monitoring

6) p-glycoprotein inducer/inhibitor- monitor and consider dec dose of cipro

7) typhoid, BCG, Cholera vaccine- acoid

8) na pico- alternative

clarithromycin interactions

1) Drugs known to prolong qtc interval- avoid or monitor ecg

2) CYP 3A4/5 sub inducers and inhibitors- sub and inh. dec dose of clar and inc for inducers

3) digoxin- caution

4) sulfonyureas- caution and inc bg monitoring

5) ssris- consider dose red of ssri

6) warfarin- monitor inr closely

7) typoid bcg and cholera vac- avoid

8) na pico- alternative

clindamycin PO interactions

1) atracurium and nondepolarizing muscle relaxers- monitor and consider dec dose

2) erythromycin- avoid

3) ty bcg and cholera vac- avoid

4) na pico- alternative

clindamycin topical interactions

none

darifenacin interactions

1) Anticholinergics- avoid

2) cyp3a4/5 inducers- monitor and consider inc dose

3) cyp 3a4/5 inhibiors- monitor and consider dec dose

4) cyp2d6 sub- avoid or moniotr

dexlansoprazle interactions

ph dependent drugs - avoid or monitor

diphenoxylate/atropine interactions

1) agents w anticholinergic effects- avoid or monitor

2) CNS dep- avoid/ monitor

3) MOAI- avoid

doxycycline interactions

1) retinoic acid derivatives- avoid (exc. adapalene, trentnoin, dextratene

2) antacids, bss, ca, iron, mg- seperate by 2h

3) digoxin- monitor and dec dose consideration

4) penicillin- avoid

5) typhoid bcg and cholera vac- avoid

6) na pico- alternative

7) carbamazepine- consider modifica

8) barbituates- monitor

Efavirenz interactions

1) boceprivir- avoid

2) cyp 2b6, 3a45, 2c9/19 sub- acoid or monitor

3) cyp 3a45 2b6 inducers and inh. - monitor

4) cisapride- contraindicated

5) oral contraceptive- use alternative wi 12 wk from cesation

6) agents that inc qtc interval- caution

elbasvir/grazoprevir

1) OAT PB1/3 and CYP 3A4/5 inducers and inh- avoid for strong, monitor for moderate and consider dose adj

2) vit k antagonists- monitor inr and consider dose inc

emtricitabine/tenofovir disoproxil interactions

1) atanzavir- concurrent use requires ritronavir booster

2) nsaids- avoid high dose or multiple

3) lopinavir, ritonavir, tipranivir, acyclovir, aminoglycosdies-monitor or dose reducation

4) p-gp substrates- monitor and consider sub dose inc

eryhtromycin interactions

1) typoid, cholera BCG vaccine- avoid

2) Na pico- alternative

3) ergot alkaloids-avoid

4) CYP3A4/5 inducers and inhbitors and sub- monitor/dose

esomeprazole interactions

1) clopridogrel- avoid

2) CYP 2c19 sub, inducers, and inhibitors- avoid or dose

3) methotrexate- avoid with high dose, monitor

4) ph dependent drugs- monitor and adjust

5) warfarin- monitor INR

famotidine interactions

1) cefidoxime- avoid

2) pH dependent drugs- monitor and seperate admin

3) dichlorphenamide- avoid

4) risedronate DR tab- avoid

finasteride interactions

none

fidaxomicin interactions

1) cholera vac- delay 2 wk

2) typhoid vac- delay 3 d

3) na pico- alternative

4) mizolastine- avoid

fluconazole interactions

1) agents that prolong qtc- avoid, astemizole and cisapride- contraindicated

2) atorvastatin- monitor for rhabdo, myopathy

3) CYP2C19/9 3A4/5 sub- avoid, monitor, dose adj

4) sulfonylureas- avoid and monitor

glecaprevir.pibrentasvir interactions

1) OATPB1/3, CYP3A4/5 inhibitors/ inducers- avoid or for moderate monitor

2) p-gp/ ABCB1 substrates- avoid or dose adj

hydroxychloroquine interactions

1) aurothioglucose- avoid

2) digoxin- avoid

3) fibrates- avoid

4) metoprolol- acoid

5) dapsone- avoid

6) rifampin- avoid

imiquimod interactions

none

ketoconazole interactions

none

lansoprazole interactions

1) antacids

2) clopridogrel

3) cyp2a4/5 and 2c19 inducers/inh

4) pH dependent drugs

levofloxacin interactions

1) antidiabetics

2) al, ca, fe, didanosine

3) C3 arryhtmatic agents or qtc interval agents

4) corticosteroids

5) NSAIDS

6) warfarin

7) typhoid, BCG and cholera vac

8) na pico

licaclotide interactions

none

lubiprostone interactions

none

maraviroe interactions

CYP3A4/5 inducers/inhibitors

metoclopramide interaction

1) atovaquone

2) amitrypitine

3) carbergoline

4) CYP2D6 inh/ind

5) cyclosporine, levodopa, tacrolimus

6) didanosine

7) digoxin, pasoconazole

8) MAOIs

9) linezolid/ SSRIs

metronidazole interactions

1) antarythmatic agents

2) amprenavir oral soln

3) cyp 3a4/5

4) cholestyramine

5) disulfram, aronabinol oral soln, alcohol

6) typhoid vac, BCG, cholera

7) na pico

8) warfarin

minocycline interactions

1) retinoic acid derivatives

2) al, ca, mag cont. antacids, zinc salts, fe, bss

3) ethinyl estrodial and other estrogen based BC

4) digoxin

5) typhoid, BCG, cholera vac

6) na pico

7) penicillin

8) warfarin

moxifloxacin PO interactions

1) antidiabetic agents

2) Al, Ca didanosine, iron

3) class 3 antiarrythmatics

4) corticosteroids

5) typhoid, BCG and cholera vac

6) na pico

7) NSADIs

moxifloxacin opthalmic interactions

none

mupirocin interactions

none

nitrofurantoin interactions

1) fluconazole

2) typhoid, BCG, cholera

3) na pico

4) norfloxacin

nystatin interactions (systemic and topical)

none

omeprazole interactions

1) clopridogrel

2) cyp2c19 ind/inh

3) ph dep drugs

4) warfarin

5) methotrexate

ondansetron interactions

1) apomorphine

2) agents that prolong qtc

pantoprazole interactions

1) cyp2c19

2) clopridogrel

3) methotrexate

4) pH dependent drugs

penicillin interactions

1) probenecid

2) typhoid, bcg, cholera vaccine

3) na pico

4) tetracyclines

phenazopyridine interactions

none

polyethylene glycol interactions

1) k+ supp

2) k sparing diuretics

3) ACEIs

rabeprazole interactions

1) cyp3a4/5, 2c19, 2c8

2) pH dependent drugs

3) clopidogrel

4) warfarin

raltegravir interactions

1) al, mg slats

2) ca carb

3) fosamprevivir

4) PPI and H2 blockers

5) rifampin

polymyxin B/trimethoprium interactions

none

rifaximin interactions

none

sofosbuvir interactions

1) p-gp inducers and inhibitors

2) amiodarone

sucralfate interactions

orally administered meds

tamulosin interactions

1) a1 blocks

2) cyp3a4/5 and 2d6

3) b blocker, ca channel blockers, and MAOIs

tizanidine interactions

1) cyp1a2 inhibitors

2) phenytoin, fosphenytoin

3) CNS dep

trimethoprium/sulfamethoxazole interactions

1) antiarrythmatic agents that prolong qtc

2) cyp2c8, 2c9, 3a4/5

3) typhoid, BCG, cholera vac

4) na pico

5) methotrexate