Liao - Cell Cycle Dynamics
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22 Terms
what is the role of cyclins & CDKs
regulate cell cycle progression
how is cdk activity regulated
cyclin degradation
which cdk + cyclin combo is found during G1 progression
cdk 4/6 + cyclin d
what cdk + cyclin combo is found leaving G1 and entering S progression (DNA replication)
cdk 2 + cyclin e/a
which cyclin + cdk combo initiates mitosis from G2
cdk 1 + cyclin a/b
what does CAK do (cyclin activating kinase)
phosphorylate CDK 1,2,4, and 6
what is the goal of CAK
promote CDK activation
what does CKI do
block CDK by preventing cyclin binding
what are the types of CKI
INK4a & Cip/Kip
how does p27KIP work
blocks both ATP & substrate binding in the cyclin-cdk complex = inactivation
how is CKI proteins degraded
by SCF (an E3 ubiquitin ligase)
how do kinase & phosphates impact CDK
they add or remove phosphorylation = activate or inactivate
what are examples of kinase or phosphate that regulate cdk function
cak kinase (activate)
wee1 kinase (inactivate)
cdc25 phosphate (activate)
what is the role of m-CDK
promote nuclear envelope breakdown & spindle formation
what is the role of APC/C + cdc25
target M-cyclin for polyubiquitination
regulate cohesin cleavage by removing securin
what is the role of APC/C + cdh1
keep cdk activity low during mitotic exit of cell cycle
what is a protein phosphatase that dephosphorylates CDK1/cyclin B to promote mitotic progression
cdc 25
what is a protein kinase complex that phosphorylates and activates CDK2/cyclin A complex
CAK
what is an E3 ubiquitin ligase that ubiquitinates substrates such as cyclin A in the early phase of mitosis
APC/C - cdc20
what is a monomeric protein that functions to activate the spindle assembly checkpoint
MAD2
what inhibits cyclin a/cdk2 kinase activity by forming a complex by binding to both cyclin a and cdk 2
p27 KIP
what is activated when kinetochores that bind to centromeres are not properly attached to spindle microtubules before anaphase through sequestration of cdc20 by MAD2
spindle assembly checkpoint