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The 5 goals of general anesthesia
hypnosis, amnesia, analgesia, akinesia, autonomic and sensory block
3 GA induction things to do before patient arrival
machine check, prep for airway management, prep of routinely administered drugs
2 GA induction things to do after patient arrival (before induction)
Connect standard ASA monitors, establish IV access
2 GA induction things to do immediately before induction
optimize patient positioning, preoxygenation using 100% oxygen
3 types of medications necessary for IV anesthetic induction
sedative (hypnotic agent), adjuvant agents, neuromuscular blocking agent (NMBA)
Perform mask ventilation until patient is adequately ___
anesthetized/relaxed
Propofol, etomidate, and ketamine are ___
sedatives
Short acting opioids, midazolam, and lidocaine are ___
adjuvant agents
Propofol’s mechanism is ___
increasing activity at inhibitory GABA synapses
Propofol induction doses have the CNS effect of producing ___
unconsciousness
Low propofol doses have the CNS effect of producing ___
conscious sedation
Propofol (has/does not have) analgesic properties
does not have
Propofol is a cardiovascular ___, it produces dose-dependent ___ in arterial BP and cardiac output
depressant, decrease
The respiratory system effects of propofol include a dose dependent decrease in ___ and ___. Ventilatory response to ___ is dimished
RR, tidal volume, hypercarbia
Induction dose of propofol is ___ IV
2-2.5 mg/kg
Sedation dose of propofol is ___ infusion
25-75 mcg/kg/min (titrate to desired effect)
Maintenance of GA propofol dose is ___
100-150 mcg/kg/min
Reduce propofol doses in ___, sick, and ___ patients
hypovolemic, elderly
An adverse effect of propofol is ___ irritation that may cause ___ during IV administartion
venous, pain
Pain from propofol may be reduced by administering ___ prior or adding ___
opioids, lidocaine
Etomidate’s mechanism of action is ___
augmenting inhibitory tone of GABA in CNS
Etomidate induction (does/does not) produce unconsciousness
does
Etomidate (does/does not have) analgesic properties
does not have
Etomidate causes (significant/minimal) changes in HR, BP, and CO
minimal
___ is frequently used for induction of GA in hemodynamically compromised patients or cardiac or neuro cases where maintenance of stable hemodynamics is essential
Etomidate
The respiratory effects of etomidate are a dose dependent decrease in ___
RR and TV
___ causes myoclonus, nausea/vomiting, venous irritation, and adrenal suppression
etomidate
Ketamine’s mechanism is ___
NMDA antagonism
___ produces a dissociative state accompanied by amnesia and analgesia
Ketamine
Ketamine (does/does not) have analgesic properties
does
Ketamine (decreases/increases) cerebral blood flow, metabolic rate, and ICP
increases
Ketamine (decreases/increases) HR and blood pressure by release of endogenous ___
increases, catecholamines
Ketamine causes very mild ___ of RR and TV
depression
Ventilatory response to hypercarbia under ketamine is (minimally/significantly) affected
minimally
Laryngeal protective reflexes are maintained longer under ___ than with other IV anesthetics. It alleviates bronchospasm
ketamine
Ketamine’s induction dose is ___ IV and ___ IM
1-2 mg/kg, 5-10 mg/kg
Ketamine’s sedation dose is ___
0.2 mg/kg (titrate to desired effect)
___ causes increased oral secretions, hallucinations, agitation, increased muscle tone, increased ICP, horizontal nystagmus, and increased IOP. Anesthetic depth is difficult to assess
Ketamine
Fentanyl dose is ___ IV
25-100 mcg (0.5-1 mcg/kg)
Lidocaine dose for suppression of airway reflexes is ___
0.5-1.5 mg/kg
Lidocaine dose to reduce pain on injection of other agents
20-30 mg
Reduce or avoid lidocaine in patients with ___
hemodynamic instability
Midazolam dose
1-2 mg (administered in 1 mg increments)
Reduce or avoid midazolam in patients with ___
hemodynamic instability
Lidocaine increases ventricular rate in patients with ___
atrial fibrillation (avoid in WPW or high-grade heart block patients)
___ provide optimum intubating conditions and facilitate surgical exposure/improve surgical conditions
muscle relaxants
A (depolarizing/nondepolarizing/either) muscle relaxant can be used for intubation
either
A (depolarizing/nondepolarizing/either) muscle relaxant can be used for intraoperative relaxation
nondepolarizing
Succinylcholine is a ___ muscle relaxant
depolarizing
Rocuronium and vecuronium are ___ muscle relaxants
nondepolarizing
Rapid Sequence Intubation is a technique used to minimize chance of ___ in patients who are high risk
pulmonary aspiration
In RSI, medications are given in rapid succession to achieve induction and relaxation so airway can be secured with ___ to minimize amount of time patient is at risk of aspiration from the time of induction when airway protective reflexes are lsot until airway is secured
cuffed ETT
History to assess difficult mask ventilation includes obesity, OSA, ___, and prior difficulty
snoring
Exam to assess difficult mask ventilation includes neck ___, facial ___, tongue ___, mouth opening, and presence/lack of teeth
circumference, hair, size
Prior difficult intubation, ___ surgery, head/neck ___or radiation are features that could cause difficult intubation
C-spine, cancer
Mallampati ___ or ___ could cause difficult intubation
3, 4
Large or loose ___ could cause difficult intubation
incisors
Short ___ distance could cause difficult intubation
thyromental
Limited ___ mobility could cause difficult intubation
neck
Inability to protrude ___ could cause difficult intubation
mandible
___ intubation is the safest approach
Awake
Awake intubation requires patient cooperation and some ___
time
For awake intubation you need to ___ airway and additional equipment
topicalize
If noninvasive awake intubation fails, your options are ___ case, consider feasibility of other options, and ___ airway access
cancel, invasive
If initial intubation attempt under general anesthesia is unsuccessful, consider ___, returning to ___ ventilation, and ___ the patient
calling for help, spontaneous, awakening
If intubation under general anesthesia is consistently difficult, attempt ___
face mask ventilation
If face mask ventilation is not adequate after failed intubation attempt, consider/attempt a ___
supraglottic airway (SGA)
If face mask ventilation is inadequate and supraglottic airway is unsuccessful, you go down the ___ pathway
emergency
The laryngeal mask airway (air Q, I-gel, etc.) is an example of a ___
supraglottic airway (SGA)
Nonemergency intubation failure pathway options include ___ introducer, ___ laryngoscopy, bronchoscopy, and intubation through ___
bougie/tracheal, video, SGA
If the nonemergency and emergency intubation pathways fail, the next step is emergency ___ airway access or waking the patient up
invasive
___ in 1727 was the first to measure arterial blood pressure
Reverend Stephen Hales
The mercury sphygmamanometer was developed in ___ by Scipione Riva-Rocci
1896
Current anesthesia related mortality is 1/___ cases
200,000-300,000
Anesthesia preop information needed includes ___ as opposed to chief complaint
case information
Obtain a (complete/focused) history and physical exam for anesthesia preop eval
focused
True or false: labs and cardiac workup studies are always needed for anesthesia preop eval
false
Surgical history with prior ___ history is a necessary part of preop focused history
anesthetic
If patient has no prior surgeries, ask about ___ of ___
family history, anesthetic complications
___ (METS), allergies, medications, NPO status and aspiration risk are important aspects of preop history
functional capacity
Functional capacity is measured in METs, the ___
metabolic equivalent
1 MET = consumption of ___
3.5 mL O2/min/kg of body weight
METs is a measure of the activity a patient can do that correlates with ___ reserve
cardiopulmonary
Patients who can tolerate ___ METs+ of activity do not need further cardiac workup
4
Risk of ___ during surgery is similar to 4 METs
ischemia
The activities that correlate with 4 METs are ___ and ___
raking leaves, gardening
___ meds and ___ meds are key ones that may need to be held prior to anesthesia
hypertension, diabetes
___ and ___ are important medication classes to ask about preop
blood thinners, pain meds/opioids
Preop physical exam includes vitals, airway exam, and at minimum ___ and ___ exams
cardiac, pulmonary
A healthy ASA _ patient having elective routine surgery does not need labs
1
Imaging is (never/rarely/always) indicated preop
rarely
Cardiac workup that includes ___, ___, and ___ is necessary in select patients
EKG, Echo, stress test
The ASA score that applies to a normal healthy patient is ___
1
The ASA score that applies to a patient with mild systemic disease is ___
II
The ASA score that applies to a patient with severe systemic disease is ___
III
The ASA score that applies to a patient with severe systemic disease that is a constant threat to life is ___
IV
The ASA score that applies to a moribund patient who is not expected to survive without the operation is ___
V
The ASA score that applies to a declared brain-dead patient whose organs are being removed for donor purposes is ___
VI
2 main techniques for regional anesthesia
neuraxial and peripheral nerve block
___ anesthesia includes spinal, epidural, and caudal
neuraxial