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statistical validity v clinical significance
effect size v how meaningful the difference actually is
social validity (who and what is it)
Wolf
following up w family of patient to see if others validate
patient uniformity myth
viewing a category of members as more similar than they actually are
Case study method
single and small group studied closely
no cause-effect conclusions
cannot be generalized
Research by correlation and epidemiology
DeLisi interviews after 9/11
most negative reaction groups where people with disorders, females, and those in the trade centers/near it
clinical trial
not a design, but a method of evaluation with placebo control groups
What does double-blind help with?
eliminates the “allegiance effect” (researcher bias)
Process research
why does it work?
Outcome research
pos/neg results of treatment, does it work?
Skinner
single-case experiments: systematic study of individuals under a variety of experimental conditions
repeated measure (not just before and after IV)
withdrawal design
multiple baseline (treatment across different times/settings)
when did the Human Genome Project begin?
1990
endophenotypes
genetic mechanisms that contribute to underlying symptoms
proband
family member WITH the trait
Lyons
conducted twin study on antisocial behavior between identical twins
Genetic linkage analysis
comparing genetic markers w a large group of people w a certain disorder
association studies
comparing gene markers to those w out the disorder
cross-sectional study
comparing people @ different ages using cohorts
cohort effect
differences between group experiences that differ form cohort
longitudinal studies
following one group overtime
*cross-generational effect
sequential designs
combination of both cross-sectional and longitudinal studies
parts of informed consent
competence
voluntarism
full information
comprehension