IL and TLR
Call Kai
Learn
Practice Test
Spaced Repetition
Match
Flashcards
Knowt Play1/41
There's no tags or description
Looks like no tags are added yet.
Name | Mastery | Learn | Test | Matching | Spaced | Call with Kai |
|---|
No analytics yet
Send a link to your students to track their progress
42 Terms
TNF-α
Pro-inflammatory; activates endothelium + fever
IFN-α / IFN-β
Produced by virally infected cells; antiviral defense
IFN-γ
TH1 differentiation; macrophage activation; IgG switching
TGF-β
Immunoregulation & tolerance
TLR-3
Recognizes dsRNA (viruses)
TLR-7
Recognizes ssRNA + guanosine
TLR-8
Recognizes ssRNA
TLR-9
Recognizes CpG DNA
TLR-10
Regulates TLR-2; suppresses inflammation
TLR-1
Recognizes triacylated lipoproteins
TLR-2
Recognizes bacterial lipoproteins
TLR-4
Recognizes LPS
TLR-5
Recognizes flagellin
TLR-6
Recognizes diacylated lipoproteins
TLR-11
Recognizes profilin (protozoa)
IL-1
Macrophage-derived; causes fever, endothelial activation, inflammation
IL-6
Acute phase protein production in liver; fever; inflammation
IL-8 (CXCL8)
Chemokine that recruits neutrophils (chemotaxis)
IL-12
Produced by DCs/macrophages; activates NK cells; drives Th1 differentiation
IL-2
T-cell growth factor; clonal expansion and survival of activated T cells
IL-4
Drives Th2 differentiation; IgE class switching; allergy and parasites
IL-5
Activates eosinophils; parasite defense
IL-17
Produced by Th17 cells; recruits neutrophils; extracellular bacteria/fungi
IL-10
Anti-inflammatory; suppresses macrophages; immune regulation
TGF-β
Immune suppression; tolerance; Treg differentiation
Th1 differentiation
IL-12
Th1 major cytokine
IFN-γ
Th1 function
Activates macrophages; defense against intracellular pathogens
Th2 differentiation
IL-4
Th2 cytokines
IL-4, IL-5, IL-13
Th2 function
Parasite defense; allergy; IgE production
Th17 differentiation
IL-6 + TGF-β
Th17 major cytokine
IL-17
Th17 function
Neutrophil recruitment; extracellular bacteria and fungi
Treg differentiation
TGF-β + IL-2
Treg cytokines
IL-10 and TGF-β
Treg function
Immune suppression; tolerance; prevention of autoimmunity
Fever cytokines
IL-1 and IL-6
Neutrophil recruitment cytokines
IL-8 and IL-17
Innate to adaptive bridge cytokine
IL-12
T-cell proliferation cytokine
IL-2
Immune suppression cytokines
IL-10 and TGF-β