Protein Denaturation

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Last updated 2:24 AM on 4/26/26
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6 Terms

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Heat & UV

Vibrations disrupt hydrogen bonds & hydrophobic interactions

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Detergents

Disrupt hydrogen bonds, hydrophobic interactions & salt bridges

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PH change

Break hydrogen binds & disrupt ionic bonds and salt bridges

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Organic compounds

Disrupt side-chain intra-molecular hydrogen bonding

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Heavy metals

Denature proteins by forming bonds with ionic AA residues or reacting with disulfide -s-s- bonds

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Agitation

Stretching of polypeptide chains until stabilizing interactions are disrupted