Antipsychotic & Related Medication Study Guide

Vocabulary-based flashcards covering FDA indications, side effects, adverse reactions, and high-yield clinical pearls for major antipsychotic medications.

Aripiprazole (Abilify)

An antipsychotic indicated for Schizophrenia, Bipolar I disorder, Adjunctive MDD, Autism irritability, and Tourette disorder; associated with impulse control disorders and serious adverse effects like NMS and TD.

Brexpiprazole (Rexulti)

Indicated for Schizophrenia, adjunctive MDD, and agitation in Alzheimer’s dementia; common side effects include weight gain, akathisia, and sedation.

Chlorpromazine (Thorazine)

Indicated for Schizophrenia, severe nausea/vomiting, and hiccups; serious adverse effects include QT prolongation, agranulocytosis, and cholestatic jaundice.

Clozapine (Clozaril)

Indicated for treatment-resistant schizophrenia and suicidality reduction; requires ANC/CBC monitoring due to risk of agranulocytosis, myocarditis, and seizures.

Haloperidol (Haldol)

Indicated for Schizophrenia, acute psychosis, and agitation; notable for having the highest EPS risk along with Perphenazine.

Lurasidone (Latuda)

Indicated for Schizophrenia and bipolar depression; must be taken with at least $350$ calories.

Olanzapine (Zyprexa)

Indicated for Schizophrenia, bipolar disorder, and treatment-resistant depression; carries a high metabolic risk and levels are lowered by smoking.

Paliperidone (Invega)

Indicated for Schizophrenia and schizoaffective disorder; known for common side effects of hyperprolactinemia, EPS, and weight gain.

Quetiapine (Seroquel)

Indicated for Schizophrenia, bipolar disorder, and adjunct MDD; among the most sedating antipsychotics with high metabolic risk.

Risperidone (Risperdal)

Indicated for Schizophrenia, bipolar mania, and autism irritability; associated with the highest prolactin elevation.

Xanomeline/Trospium (Cobenfy)

A muscarinic-based schizophrenia medication; adverse effects include urinary retention, tachycardia, and glaucoma risk.

Highest Metabolic Risk Medications

Olanzapine, Clozapine, and Quetiapine.

Highest EPS Risk Medications

Haloperidol and Perphenazine.

Deutetrabenazine

A medication used to treat tardive dyskinesia.

Clozapine Smoking Interaction

Smoking lowers the blood levels of this medication.

Most Sedating Antipsychotics

Chlorpromazine, Quetiapine, Olanzapine, and Clozapine.

Aripiprazole Monitoring

Requires monitoring of Weight/BMI, lipids, glucose/A1c, BP, and EPS/AIMS.

Serious Adverse Effects of Clozapine

Agranulocytosis, myocarditis, seizures, ileus, and NMS.