Week 4 Microcytic Anemia and Hemoglobin Synthesis

These flashcards cover key concepts related to microcytic anemia, hemoglobin synthesis, associated disorders, and diagnostic indicators.

Microcytosis

Disorders where red blood cells are smaller than normal.

MCV (Mean Cell Volume)

The average size of red blood cells, used to classify anemias.

Normal MCV range

An MCV falling between 80 and 100.

Micronormocytic

Describes red blood cells that are smaller than normal, with an MCV of 79 or below.

Hemoglobinization

The process of hemoglobin being synthesized in red blood cells.

Iron deficiency anemia

A type of anemia caused by inadequate iron that leads to reduced heme synthesis.

Hepcidin

A key hormone that regulates plasma iron levels, negatively affecting iron absorption.

Basophilic stippling

Coarse granules seen on red blood cells that can indicate abnormal hemoglobin synthesis.

Ferritin

The primary storage form of iron in the body, used to assess iron stores.

Congenital sideroblastic anemia

A rare condition where a genetic defect affects heme synthesis, leading to microcytic anemia.

Thalassemia

An inherited blood disorder characterized by reduced or absent synthesis of alpha or beta globin chains.

Pencil cells

Elongated red blood cells seen in iron deficiency anemia.

Hypochromia

Condition where red blood cells have less color due to low hemoglobin content.

Anemia of chronic disease

Anemia associated with chronic inflammatory conditions that leads to iron retention and reduced availability for erythropoiesis.

Protoporphyrin

The base molecule for heme synthesis that binds with iron to form heme.

Ring sideroblasts

Developing red cells in congenital sideroblastic anemia that fail to incorporate iron into heme, leading to a characteristic ring of iron.

Lead poisoning

A condition resulting from lead exposure that interferes with hemoglobin synthesis, causing varying degrees of anemia.