Leukocyte disorders
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42 Terms
What neutrophil count threshold defines neutrophilia in the notes?
7500/µL
Which neutrophilia is normal and lacks toxic changes?
Physiologic
Which neutrophilia shows toxic granulations, vacuoles, and Döhle bodies?
Pathologic
Which reaction shows a left shift and increased LAP score?
Leukemoid
Which reaction shows immature cells in the peripheral blood smear?
Left shift
Which functional disorder has defective respiratory burst?
CGD
Which enzyme is deficient in chronic granulomatous disease?
NADPH oxidase
Which disorder has abnormal fusion of primary and secondary granules?
Chediak-Higashi
Which gene is mutated in Chediak-Higashi syndrome?
LYST
Which granulocyte abnormality has peroxidase-positive gigantic granules?
Chediak-Higashi
Which nuclear abnormality is linked to megaloblastic anemia?
Hypersegmentation
Which anomaly is a hyposegmentation disorder?
Pelger-Huet
Which inherited cytoplasmic anomaly has giant platelets?
May-Hegglin
Which gene mutation causes May-Hegglin anomaly?
MYH9
Which inherited anomaly has large azurophilic mucopolysaccharide granules?
Alder-Reilly
Which disease has glucocerebrosidase deficiency?
Gaucher
Which disease shows crumpled tissue paper macrophages?
Gaucher
Which disease has sphingomyelinase deficiency?
Niemann-Pick
Which disease shows foamy macrophages?
Niemann-Pick
Which virus causes infectious mononucleosis?
EBV
Which viral infection targets B cells and creates reactive T cells?
Mononucleosis
Which IM-like infection lacks reactive lymphocytes?
CMV
Which infection is the most common transplacental infection?
CMV
Which test is negative in CMV IM-like infection?
Heterophile
Which viruses cause infectious lymphocytosis?
Adenovirus/Coxsackie
Which malignant leukocyte disorder category includes acute lymphoproliferative?
Malignant
Which malignant leukocyte disorder category includes acute myeloproliferative?
Malignant
Which malignant leukocyte disorder category includes chronic leukemias?
Malignant
Which malignant leukocyte disorder category includes lymphoid malignancies?
Malignant
Which malignant leukocyte disorder category includes MDS?
Malignant
Which malignant category includes CML?
Chronic leukemia
Which malignant category includes essential thrombocythemia?
Chronic leukemia
Which malignant category includes polycythemia vera?
Chronic leukemia
Which malignant category includes myelofibrosis?
Chronic leukemia
Which malignant category includes CLL?
Chronic leukemia
Which malignant category includes hairy cell?
Chronic leukemia
Which malignant category includes prolymphocytic?
Chronic leukemia
Which category includes multiple myeloma?
Lymphoid
Which category includes Waldenstrom?
Lymphoid
Which category includes Hodgkin?
Lymphoid
Which category includes Non-Hodgkin?
Lymphoid
Which category includes mycosis fungoides?
Lymphoid