TrKB receptor pathway

PI3K/Akt Pathway

A signaling pathway activated by TrkB that promotes cell survival and growth by enhancing metabolism and preventing apoptosis.

What role does Akt play in the PI3K/Akt pathway following TrkB activation?

Akt helps the cell survive and grow by promoting cell metabolism and blocking apoptosis.

MAPK/ERK Pathway

A signaling pathway activated by TrkB that stimulates cell division and growth through the activation of Ras, MEK, and ERK.

What happens to ERK in the MAPK/ERK pathway when TrkB is activated?

ERK moves into the cell's nucleus and activates genes that promote cell division and growth.

PLCγ pathway

A signaling pathway involved in influencing calcium signaling and cytoskeletal dynamics, important for cell survival, growth, and division.

How does TrkB signaling affect cancer cells, particularly in lung cancer?

TrkB receptors can be overactive in cancer cells, allowing them to grow and survive more easily, presenting a target for treatments.

BDNF

Brain-derived neurotrophic factor, a growth factor that binds to TrkB and activates signaling pathways important for cell survival and growth.

Apoptosis

The process of programmed cell death that is inhibited by Akt in the PI3K/Akt pathway.