TrKB receptor pathway

(tropomyosin receptor kinase B)

Sure! Here's a simplified explanation of the two main pathways involved in TrkB receptor signaling:

1. PI3K/Akt Pathway:
   
   

   • When TrkB (a receptor on the cell surface) binds to its growth factor (like BDNF), it activates a protein called PI3K.

   • PI3K then activates another protein called Akt.

   • Akt helps the cell survive and grow by promoting processes like cell metabolism and blocking cell death (apoptosis).

   • This pathway is important for cancer cell survival and growth.

2. MAPK/ERK Pathway:
   
   

   • Similarly, when TrkB binds to its ligand, it activates a protein called Ras.

   • Ras then activates a chain of proteins, including MEK and ERK.

   • ERK moves into the cell's nucleus and activates genes that promote cell division and growth.

   • This pathway is involved in helping cancer cells divide and proliferate.

3.   PLCγ pathway: Influences calcium signaling and cytoskeletal dynamics.

When TrkB binds to BDNF, it sends signals inside the cell that help the cell survive, grow, and divide. This signaling is very important for cell growth and survival, especially in the nervous system.

In cancer, including lung cancer, TrkB receptors can be overactive. This means the cancer cells can grow and survive more easily, making TrkB an important target for potential cancer treatments.