Pharm 2 Final: Autocoid & Serotonergic Drugs

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Last updated 1:58 PM on 4/25/26
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7 Terms

1
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Diphenhydramine (Benadryl)

MOA: First-generation antihistamine; high affinity for central H1 receptors. Use: Allergies, motion sickness, insomnia, severe pruritis. SE: Sedation; anticholinergic effects.

2
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Hydroxyzine (Atarax)

MOA: First-generation antihistamine; high affinity for central H1 receptors. Use: Allergies, motion sickness, insomnia, pruritis, anxiety. SE: Less sedating than diphenhydramine; anticholinergic effects.

3
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Cetirizine (Zyrtec)

MOA: Second-generation antihistamine. Use: Allergies. SE: Lacks antiemetic activity.

4
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Buspirone (Buspar)

MOA: 5-HT1A partial agonist. Use: Anxiety and depression. SE: Use caution with SSRIs.

5
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Sumatriptan (Imitrex)

MOA: 5-HT1B and 5-HT1D serotonin agonist; produces vasoconstriction. Use: Acute migraine treatment. SE: Caution with SSRIs; can cause coronary vasospasm; avoid in patients with angina/CAD; risk of serotonin syndrome.

6
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Ondansetron (Zofran)

MOA: 5-HT3 antagonist. Use: Nausea and vomiting (including chemotherapy-induced). SE: Higher doses associated with QTc prolongation.

7
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Alprostadil

MOA: Naturally occurring prostaglandin (PGE1); vasodilatory properties. Use: Maintain ductus arteriosus patency in neonates; erectile dysfunction. SE: Can cause priapism.