COMPOUNDS ASSOCIATED WITH NEURONAL INJURY (NEURONOPATHIES)

Dementia

Encephalopathy (humans)

Learning deficits

Neurological Findings of Aluminum

Spongiosis cortex

Neurofibrillary aggregates

Degenerative changes in cortex

Cellular basis of Neurotoxicity in Aluminum

Not reported in humans

Hind limb paralysis (experimental animals)

Neurological Findings in 6-Amino-nicotinamide

Spongy (vacuolar) degeneration in spinal cord, brainstem, cerebellum

Axonal degeneration of the peripheral nervous system (PNS)

Cellular basis of Neurotoxicity in 6-Amino-nicotinamide

Encephalopathy (acute)

Peripheral neuropathy (chronic)

Neurological Findings in Arsenic

(PNS) Brain Swelling and hemorrhage (acute)

Axonal degeneration in PNS (chronic)

Cellular basis of Neurotoxicity in Arsenic

Insufficient data (humans)

Convulsions, ataxia (primates)

Neurological Findings in Azide

Neuronal loss in cerebellum and cortex

Cellular basis of Neurotoxicity in Azide

Emotional disturbances

Encephalopathy

Myoclonus

Neurological Findings in Bismuth

Neuronal loss

basal ganglia

Purkinje cells of cerebellum

Cellular basis of Neurotoxicity in Bismuth

Encephalopathy

Delayed parkinsonism/dystonia

Neurological Findings in Carbon monoxide

Neuronal loss in cortex

Necrosis of pallidus

Focal demyelination

Blocks oxygen binding site of hemoglobin and iron binding sites of brain

Cellular basis of neurotoxicity in Carbon monoxide

Encephalopathy (secondary to liver failure)

Neurological Findings in Carbon tetrachloride

Enlarge astrocytes in striatum, globus pallidus

Cellular basis of Neurotoxicity in Carbon tetrachloride

Optic neuritis

Peripheral neuropathy

Neurological Findings in Chloramphenicol

Neuronal loss (retina)

Axonal degeneration (PNS)

Cellular basis of Neurotoxicity in Chloramphenicol

Coma

Convulsions

Rapid death

Delayed parkinsonism/Dystonia

Neuronal Findings in Cyanide

Neuronal degeneration

Cerebellum and globus pallidus

Focal demyelination

Blocks cytochrome oxidase/adenosine triphosphate production

Cellular basis of Neurotoxicity in Cyanide