Anti-neoplastics quiz
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32 Terms
How do Alkylating agents work
Bind DNA and insert and alkyl group
Leads to change in structure
Inhibition of transcription and replication
Apoptosis if the cell is not repaired
How do Vinca Alkaloids work
Bind to or inhibit formation of microtubules
Prevent formation of mitotic spindles
How do Antitumour antibiotics work
Topoisomerase inhibition breaks DNA strands
Intercalated with DNA prevents transcription
Free radical formation damages DNA
How do Platinating agents work
Platinum binds both with and between strands of DNA
Inhibits transcription and replication
Cell death if damage is not repaired
How do Anti-metabolised worl
Interact with DNA production but differing mechanisms
Crosses blood brain barrier
How does L-asparaginase work
Combines with an enzyme to produce L-asparctic acid
Causes malignant lymphocyte death
How do Glucocorticoids work
Bind to cytosolic receptors
Transport into nucleus where it acts as a transcription factor
Increasing anti-inflammatory protein expression
Reduce inflammatory protein production
How do NSAIDs work
Inhibit COX1 and COX2
Reduce prostablandingsand thromboxanes
Reduce inflammation and pain
What is Cyclophosphamide
Alkylating agent
What is Chlorambucil
Alkylating agent
What is Melphalan
Alkylating agent
What is Lumustine
Alkylating agent
What is Temozolamide
Alkylating agent
What is Procarbazine
Alkylating agent
What is Vincristine
Vinca Alkaloid
What is Vinlastine
Vinca Alkaloid
What is Vinorelbine
Vinca Alkaloid
What is Doxorubicin
Antitumour antibiotic
What is Epirubicin
Antitumour antibiotic
What is Mitoxantrone
Antitumour antibiotic
What is Acitinomycin D
Antitumour antibiotic
What is Bleomycin
Antitumour antibiotic
What is Cytosine
Anti-metabolite
What is Arabinoside
Anti-metabolite
What is Methotrexate
Anti-metabolite
What is Rabacfosadine
Anti-metabolite
What is Gemcitabine
Anti-metabolise
What is 5-fluorouracil
Anti-metabolite
What is Prednisolone
Glucocorticoids
What is Dexamethasone
Glucocorticoids
What is Meloxicam
NSAID
What is Piroxicam
NSAID