antiemetic/nausea

anticholinergic (ACh blockers) indications

motion sickness, secretion reduction before surgery, nausea and vomiting

anticholinergic AE

• dizziness, drowsiness, disorientation

• tachycardia

• blurred vision, dilated pupils, dry mouth

• difficult urination, constipation

• rash, erythema,

antihistamine drugs (H1 receptor blockers) indications

motion sickness, nonproductive cough, sedation, rhinitis, allergy symptoms, nausea, and vomiting

antihistamine drugs (H1 receptor blockers) AE

dizziness, drowsiness, confusion

blurred vision, dilated pupils, dry mouth

urinary retention

antidopaminergics indications

psychotic disorders, intractable hiccups, nausea and vomiting

antidopaminergics AE

• orthostatic hypotension, tachycardia

• extrapyramidal symptoms tardive dyskinesia, headache

• blurred vision, dry eyes

• dry mouth, nausea, anorexia, constipation

• urinary retention

prokinetic drugs indications

• delayed gastric emptying, gastroesophageal reflux, nausea and vomiting

prokinetic drugs AE

• hypotension, supraventricular tachycardia

• sedation, fatigue, restlessness, headache, dystonia

• dry mouth, nausea, vomiting, and diarrhea

serotonin blockers indications

nausea vomiting assc. with chemotherapy

postoperative nausea vomiting

Serotonin blockers AE

• headache, diarrhea

• rash, bronchospasm, prolonged QT interval

tetrahydrocannabinol indications

• nausea and vomiting - chemotherapy

• anorexia assc. with weight loss - AIDS and cancer

tetrahydrocannibinol AE

drowsiness, dizziness, anxiety, confusion, euphoria, visual disturbances, dry mouth

Doxylamine succinate and pyridoxine hydrochloride (Diclectin) - antinausea

• Doxylamine succinate (antihistamine) and pyridoxine hydrochloride (vitamin B6)

• antinausea and antiemetic effects

diclectin indications

nausea and vomiting during pregancy

drug given 4-6 hours prior to symptoms

nighttime dose effective in morning

(two tablets at nighttime, one in morning, another midafternoon)

education:

• warn pt before any hazardous tasks like driving

• taking with alcohol may cause severe CNS depression

• change position to slowly avoid hypotensive effects

• take 1-3 hrs before chemotherapy drug

ginger indications

nausea and vomiting - chemo, morning/motion sickness

ginger AE

anorexia, nausea and vomiting, skin rxns

ginger interactions

• incr. absorption of oral medications

• incr. bleeding risk with anticoagulants