Adverse Effects PHARM QUIZ 5

Aspirin

GI bleed, bleeding, renal impairment, ototoxicity, Salicylism, Reye’s Syndrome

Acetaminophen

hepatotoxicity (due to metabolite), glutathione depletion

Celecoxib

GI bleeding, renal impairment

NSAIDs

GI bleeding, bleeding, renal impairment, ototoxicity, MI risk

Probenecid

GI upset (nausea/vomit, anorexia, take with food), renal impairment, drink water

Xanthine Oxidase Inhibitors

GI upset (nausea/vomit, diarrhea, abdomen pain), hypersensitivities, skin rash

Colchicine (Colcrys)

GI upset (nausea/vomit, diarrhea, abdomen pain, take with food), myleosuppression, rhabdomyolysis

Ergotamine Tartrate

nausea/vomit, HTN, HR changes, dependence, ergotism

Urbrogepant (Ubrelvy)

nausea/vomit

Erenumab

constipation, muscle cramping

Levadopa

nausea/vomit, dyskinesia, orthostatic hypotension, HR changes, darkened sweat & urine, psychosis, CNS agitation

Carbidopa

decreases Levadopa cardio & nausea/vomit symptoms

Pramiprexole (Mirapex)

daytime sleepiness, insomnia, hallucinations, impulse control

Entracapone (Comtan)

dyskinesia, orthostatic hypotension, hallucinations

Disulfiram

flushing, sweating, nausea/vomit, palpitations

Naltrexone

nausea/vomit

Opioids

euphoria/dysphoria, miosis, constipation, urinary retention, nausea/vomit, sedation, respiratory depression, biliary colic, neurotoxicity, ICP, birth defects, pruritis/uticaria

Methylnaltrexone

diarrhea, flatulence, abdomen pain, nausea, dizziness