Genetics of Breast Cancer and Associated Genes

Vocabulary flashcards detailing genetic mutations, their clinical presentations (sporadic vs. familial, triple negative, male breast cancer), and their corresponding chromosomal locations according to the lecture notes.

B 53

The most common gene mutated in sporadic breast cancer.

Burca

The most common gene associated with familial breast cancer.

Burca one

A gene linked with breast and ovarian cancers that are often aggressive and triple negative; located on chromosome $17$.

Triple negative breast cancer

Cancers that are often associated with Burca one, though the most common mutation remains P 53.

P 53

The most common mutation in triple negative breast cancers, located on chromosome $17$.

Burca 2

The gene most commonly associated with CA breast in men, prostate cancer, and pancreas cancer; located on chromosome $13$.

Chromosome $17$

The chromosome housing P 53, Burca one, and NF1.

Chromosome $13$

The chromosome housing RB, Burca 2, and ATP 70.

NF1

A gene located on chromosome $17$, which is categorized with the 'bigger brothers.'

RB

A gene located on chromosome $13$, categorized with the 'smaller brothers.'

ATP 70

A gene associated with Wilson's and located on chromosome $13$.