memory dysfunction

psyc 301

retrograde amnesia

the loss of memories from before the injury, very rare for it to impact childhood memories that have been preserved for a long time

anterograde amnesia

the loss of memories from after the injury

patient HM

lost most of his hippocampus after a bilateral medial temporal lobectomy to treat his epilepsy and got anterograde amnesia

HM memory duration

he was able to keep a conversation and do a digit span task which suggests working memory is separate

HM unconscious memory

he had no problem with procedural tasks, pavlovian conditioning, and priming

explicit/declarative memory

the conscious, intentional recollection of factual information, previous experiences, and concepts

implicit/non-declarative memory

long-term, unconscious memory that allows individuals to perform tasks and behaviors automatically without deliberate effort or conscious recall

episodic memory (declarative)

personally experienced events

semantic memory (declarative)

facts, meanings, concepts, and knowledge about the external world

where explicit memory is processed

hippocampus, frontal and temporal lobes

where implicit memory is processed

cerebellum and basal ganglia

cellular basis for memory

long term potentiation

glutamate receptors involved in LTP

AMPA and NMDA