Cytokines & Effector TH cells

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Last updated 11:32 AM on 4/12/26
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8 Terms

1
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Polarizing cytokines, master gene regulator, and effector cytokines for peripheral T-reg cells

IL-2 and TGF-beta; FoxP3 transcription factor; IL-10 & TGF-beta

2
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Polarizing cytokines, master gene regulator, and effector cytokines for TH17

IL-6, IL-23, and TGF-beta; RORyt transcription factor; IL-17A, IL-17F, and IL-22

3
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Polarizing cytokines, master gene regulator, and effector cytokines for TH2

IL-4; GATA3 transcription factor; IL-4, IL-5, and IL-13

4
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Polarizing cytokines, master gene regulator, and effector cytokines for TH9?

IL-4 and TGF-beta; IRF4 and PU.1 transcription regulators; IL-9

5
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Polarizing cytokines, master gene regulator, and effector cytokines for T(FH)

IL-6 and IL-21; BCL-6 transcriptional repressor; IL-4 and IL-21

6
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Polarizing cytokines, master gene regulator, and effector cytokines for TH1

IL-12, IFNy, and IL-18; T-Bet transcription factor; IFNy, TNF, and IL-2

7
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Polarizing cytokines, master gene regulator, and effector cytokines for TH22

IL-6 and TNF; AHR transcription factor; IL-22

8
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What does BCL-6 do?

Inhibits T-bet, GATA3, and RORyt allowing for polarization to the T(FH) cell type