Clostridium difficile associated diarrhea (CDAD)

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Last updated 2:41 PM on 4/22/26
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8 Terms

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Clostridium difficile associated diarrhea (CDAD) affects ___ __ North Americans per year

3.5 million

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Clostridium difficile associated diarrhea (CDAD) is the cause of __ of all antibiotic associated diarrhea in humans

25%

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Fatality rate of Clostridium difficile associated diarrhea (CDAD)

27 - 44% if untreated

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Clostridium difficile produces 2 toxins:

Toxin A is an enterotoxin

• Results in fluid secretion

Toxin B is a cytotoxin

• Results in epithelial necrosis

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Clostridium difficile causes damage in humans through

Pseudo-membranous colitis

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Clostridium difficile causes damage in animals through

Acute necrotizing enterocolitis

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Clostridium difficile is diagnosed by

Fecal culture - not all strains produce toxins

Demonstrate toxins in fecal sample (GOLD Standard) - PCR (detect toxin genes)

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Treatment of Clostridium difficile

anti-C. difficile-drugs - Tylosin

Fluid therapy

Sanitation