Insecticide MOA:Everything else

What is the target/moa for muscle insecticides?

Ryanodine receptors (RyR)

How do the muscle insecticdes work?

They force open gates resulting in calcium flooding. This caused contraction and death.

What does group 28 Do?

They are the ryanodide receptor modulators that force open channels. (also systemic)

How do the TRPV modulators work?

They cause the insect to go blind and deaf due to modulating the muscle to be in a stretch position.

How quick is group 28

They quickly stop feeding and moderately kill

What is the key difference in group 9 and 29?

Group 29 has an unknown target site.

What is the mortality for group 29 and 9?

Fast feeding stopping but slow mortality.

What do group 9 and 29 target?

TRPV and the

What are insect growth regulators going to be targeting?

The chitin, membranes, Ecdysone(when) and JH (What instar)

What groups target chitin synthesis inhibitors?

10, 15 and 16.

What is group 15 and 16 main downside?

It has no adult activity and kills only at molting (chitin)

When does group 10 hit?

Only the immature stages

How fast are 10 15 and 16?

They are very slow at action and mortality

What are ecdysones and JH’s purpose?

Ecdysone is what signals to molt. JH is what stops when the next stage should be molted into.

What group is the JH mimic

group 7

What group is the Ecdysone mimic?

group 18

group 18 speed?

action is fast but mortality is slow

group 7 speed?

action and mortality are slow but it relies on molting.

When can group 7 work?

On eggs or the final instars of nymphs

What group targets acetyl CoA carboxylase?

group 23

how fast is group 23?

Slow mortality and action

What are the target sights of the IGR’s?

Ecdysone receptor, JH receptor, chitin synthesis proteins, and Fatty acid synthesis (Acetyl CoA Carboxylase).

What ion channels are the target sights of muscle inhibitors?

RyR and TRPV

What groups disrupt complex 1-4 in cellular respiration?

20, 21, 24, 25, and 12 13

What group uncouples H in respiration?

13

How fast are the respiration inhibitors?

Faster than IGR but slower than nerves.

What types of pesticides are generally hitting the midgut?

Biopesticides

What group are BT’s

group 11

What group are baculoviruses?

Group 31

How fast are the midgut groups?

Slow death and mortality

Cheat sheet for the groups

Nerve and Muscle toxins are fastest action

Fast action

Fast to slow mortality

Growth regulators generally active at next molt

May have rapid activity (session of feeding)

Mortality generally slow

Interference with respiration generally moderate death

Disruption of midgut – slow activity, slow death

What is the only slow muscle mortality? WHy

TRPV in group 9 and 29. They cause deafness and mobility issues reulting in fast action but slow death.

How does group 28 actually work?

It floods the muscle with Ca2+ resulting in contractions and death