Innate Immunity 1 - Anatomic Barriers

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Last updated 3:20 AM on 5/24/26

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Effector response

Differs depending on anatomic location

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Pathogens

Induce direct and indirect tissue damage

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Skin

A watertight lipid layer

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Lung epithelium

Mucus producing goblet cells and cilia for the expulsion of particles

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Gut epithelium

Paneth cells secrete anti-microbial peptides (a-defensins, RegIII)

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Lysozyme

In mucus, saliva, tears ; attacks the peptidoglycan component of bacterial cell walls