Nutri. Nutrients-Minerals (1)

What tissues is cobalt distributed in?

Liver, kidney, adrenal and bone

What is the function of Cobalt?

In vitamin B12 it is a cofactor for enzyme reactions (glucose metabolism and isomerase reactions)

What is the metabolism of Cobalt?

Poorly absorbed, 80% of oral dose appears in feces and is excreted through kidney (urine)

What are the signs of Cobalt deficiency?

Wasting disease (ruminants) and anemia

What tissue is iodine distributed in?

Thyroid

What is the metabolism of Iodine?

Concentrated in egg yolk and milk, has transporters general halide and specific I2

What are the deficiency signs of Iodine?

Reduced basal metabolic rate, goiter and in newborns hairless and dry thickened skin

What is iron a component of?

Hemoglobin and myoglobin

What tissues is iron distributed in?

Red blood cells and muscle (60-70%) and labile stores in the liver, spleen (20%)

What is the metabolism of Iron?

Absorbed as Fe2+ (5-10% oral dose), little excretion under normal conditions, urinary loss can occur if consumed in excess and transported in blood bound to transferrin

What are the deficiency signs of Iron?

Anemia

What is the tissue distribution of Copper?

Liver, brain, kidneys, heart, eye and haril/wool

What are the functions of Copper?

Required for activity of enzymes involved in Fe metabolism, elastin/collagen formation, melanin production, integrity of CNS and normal hair/wool regulation

What is the metabolism of Copper?

Site of absorption varies with species, transport bound to albumin and excreted mainly in the bile

What factors affect Copper absorption?

Dietary Mo

What are the deficiency signs of Copper?

Anemia, incoordination and ataxia, bone abnormalities and alopecia/slow growth

What was selenium first recognized as?

Toxic

What is selenium a cure for and in which animal?

Muscular dystrophy in lambs

What is the tissue distribution of selenium?

All cells of the body (highest in liver, kidney and muscle)

What is the function of selenium?

Component of glutathione peroxidase

What is the metabolism of Selenium?

Absorption relatively efficient (35-85%) and plant sources more available than inorganic

What are the deficiency signs of Selenium?

Nutritional muscular dystrophy and white muscle disease (lambs)