Pharm 2 Final: Neurodegenerative Disease Drugs

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Last updated 1:58 PM on 4/25/26
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6 Terms

1
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Levodopa

MOA: Taken up by dopamine neurons and converted to dopamine. Use: Parkinson's disease. SE: Movement disorders from excess dopamine.

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Carbidopa

MOA: Structural analog to levodopa; reduces peripheral conversion of levodopa to dopamine, increasing CNS levodopa availability. Use: Adjunct to levodopa in Parkinson's. SE: Reduces GI and cardiovascular side effects of levodopa.

3
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Bromocriptine

MOA: D2 receptor agonist and D1 receptor antagonist. Use: Adjunct to levodopa in advanced Parkinson's. SE: N/A.

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Ropinirole

MOA: D2 receptor agonist. Use: Early Parkinson's; restless leg syndrome. SE: N/A.

5
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Benztropine

MOA: Anticholinergic. Use: Adjunctive treatment in Parkinson's (also used for EPS management). SE: Anticholinergic side effects.

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Donepezil

MOA: Reversible cholinesterase inhibitor; increases acetylcholine in the CNS. Use: Alzheimer's disease. SE: N/A.