Studied by 109 people
SAS 7
Aerosols
refers to various systems ranging from those colloidal to systems consisting of pressurized packages
Pharmaceutical aerosol
an aerosol product coming therapeutically active ingredients dissolved, suspended, or emulsified in a propellant or nature of solvent and propellant
Oral aerosols
are intended for administration as fine, solid particles or as liquid mists and are used for their local action in the nasal area, throat, or lungs
Propellants
responsible for developing the proper pressure within the container and expels the product while the valve is opened
Containers
a component of aerosol package that must withstand pressures as high as 140 to 180 psig at 130 degrees Fahrenheit
Tinplate container
consists of a sheet of steel plate that has been electroplated on both sides with tin
Soudronic system
it is based on electronically controlled resistance welding method that uses a copper wire as an electrode
Conoweld system
it passes the folded body through two rotating electrode rings
Aluminum containers
used to manufacture extruded (seamless) aerosol containers
Stainless Steel containers
are limited to smaller sizes but extremely strong and resistant to most materials and have been used for inhalation aerosols
Glass containers
are available with or without coating with corrosion problems being eliminated and has a greater degree of freedom in the design of the container
Continuous spray valve
it is assembled using high-speed production techniques
Ferrule or Mounting Cup
it is used to attach the valve proper to the container
Valve body or Housing
it contains an opening at the point of attachment of the dip tube
Gasket
it is made from Buna-N and Neoprene rubber
Spring
it serves to hold the gasket in place
Dip tube
it is made from polyethylene or polypropylene
Metering valves
applicable to the dispensing of potent medication
Actuators
ensures that the aerosol product is delivered in the proper and desired form
Spray actuators
an actuator which can be used with pharmaceuticals intended for topical use such as spray-on bandage, antiseptics, local anesthetics, and foot preparations
Foam actuators
an actuator which consist of relatively large orifices ranging from approximately 0.070 inch to 0.125 inch or greater
Solid-stream actuators
an actuator utilized in the dispensing of semisolid products such as ointment
Solution system
a two-phase system that consists of a vapor and liquid phase
Water-based system
a system that can be used to replace all parts of the non-aqueous solvents and can produce spray or foam
Ethanol
it can be used as a co-solvent to solubilize propellant in water
Suspension or Dispersion system
it involves dispersion of active ingredient in the propellant or mixture of propellants
Foam systems
it consists of active ingredients that are dispensed as a stable or quick-breaking foam
Aqueous Stable Foams
a type of foam that is used with hydrocarbon and compressed gas propellants
Nonaqueous Stable Foams
a type of foam that is used with glycols such as polyethylene
Quick-breaking Foams
a type of foam where the propellant is in the external phase
Thermal foams
a type of foam that is used to produce warm foam for shaving
Intranasal aerosols
it is intended to deposit medications into nasal packages for local or systemic effect
Pressure Filling Apparatus
it consists of a pressure burette capable of metering small volumes of liquified gas into the aerosol container under pressure
Cold Filling Apparatus
it consists of an insulated box fitted with copper tubing and the tubings are ccoiled to increase the area exposed to cooling
Gas chromatography
it is used to determine the identity of the propellant
Leak testing
a means of checking the crimping of the valve and must be available to prevent defective containers due to leakage
Spray testing
it serves to clear the dip tube of pure propellant, of pure concentrate, and to check for defects in the valve and the spray pattern
Spray testing
for metered valves, it serves to prime the valve so that it is ready for use by the consumer
Delayed release
it is also called enteric-coated tablets
Delayed release
it refers to systems that use repetitive, intermittent dosing of a drug
Sustained Release
it refers to systems that are designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time
Controlled Release
it refers to systems that achieves slow release of drug over an extended period of time
Extended Release
it refers to systems that release the drug slower than the normal manner at predetermined rate
Site Specific Targeting
in this case, the target is adjacent to or in the diseased organ or tissue
Receptor Targeting
in this case, the target is the particular receptor for a drug within an organ or tissue
Prolonged Release System
it prevents very rapid absorption of the drug, which could result in an extremely high peak plasma drug concentration
Dose dumping
a phenomenon where by relatively large quantities of drug in a sustained release formulation is rapidly released, introducing potential toxic quantities of the drug into the systemic circulation
Half-life
an index of its residence time in the body
Diffusion Sustained System
characterized by the release rate of a drug being dependent on its diffusion through an inert membrane barrier
Reservoir type
in this system, water insoluble polymeric material encases a core of drug
Matrix type
in this system, the drug is dispersed as solid particles within a porous matrix formed of a water-insoluble polymer
Ion exchange
it uses resins composed of water-insoluble cross-linked polymers
Microencapsulation
a means of applying relatively thin coating to small particles of solids or droplets of liquids and dispersions
Core material
defined as the specific material to be coated and can be solid or liquid in nature
Coating material
it should be capable of forming a film that is cohesive with the core material
Wurster process
it consists of the dispersion of solid, particulate core materials in a supporting air stream and the spray-coating of the air-suspended particles
Multiorifice-Centrifugal Process
a mechanical process for producing microcapsules that utilizes centrifugal forces to hurl a core material particle
Spray Drying
the coating solidification is effected by rapid evaporation of a solvent in which the coating material is dissolved
Spray Congealing
the coating solidification is accomplished by thermally congealing a molten coating material or by solidifying a dissolved coating
Polymerization
it utilizes polymerization techniques to form protective microcapsule coatings in situ
Note 
Flashcard (36)