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preventing the common cold
-wash hands (soap and water preferred)
-avoid touching face
-avoid contact with infected
-clean surfaces
cholinergic stimulation
a runny nose due to the COMMON COLD is due to _______________________ which increases mucous gland activity
1 week
the typical common cold lasts around ______________
if inoculated w common cold, ___________ of people will experience symptomatic illness
sore throat (common cold)
early symptom, can treat with oral analgesics
runny nose (common cold)
brief early symptom, can treat with 1st gen antihistamines
nasal congestion (common cold)
almost all patients experience, can treat with decongestants
cough (common cold)
end stage symptom, treatment depends on the type
systemic complaints like fever and malaise (common cold)
not common but if present can treat with oral analgesics
oral analgesic for common cold
NSAIDs or acetaminophen
BUT
NSAIDs must be taken with food so acetaminophen is preferred
drink fluids
someone with a common cold should ___________________ to relieve symptoms
NO NO NO NO NO NO ITS CHOLINERGIC
histamine is the cause of runny nose due to a common cold
1st generation antihistamines
MIGHT relieve runny nose from common cold due to anticholinergic activity
adverse effects of 1st gen antihistamines
-sedation
-narrow angle glaucoma
-can worsen BPH
doxylamine
nyquil, unisom
MOST sedating 1st gen antihistamine
diphenhydramine
benadryl
2nd most sedating 1st gen antihistamine
brompheniramine
Dimetapp
3rd most sedating 1st gen antihistamine
chlorpheniramine
Chlor-Trimeton
LEAST sedating 1st gen antihistamine
age for 1st gen antihistamines
>6 years old
dosage forms for treating nasal CONGESTION
-oral
-topical (nasal sprays and vapor inhalers)
age for ORAL decongestants
>4 years old
pseudoephedrine
Sudafed
the best oral nasal decongestant
cardiovascular disease
oral nasal decongestants should NOT be used in patients with _________________________
oral decongestant side effects
-jitters
-insomnia
-anxiety
immediate release pseudoephedrine tablets
30mg q 4-6 hours
MAX 4 doses/24 hours
Max dose of pseudoephedrine
240 mg/day
sustained release pseudoephedrine tablets
120mg q 12 h
extended release pseudoephedrine tablets
240mg q 24 h
issues w/ pseudoephedrine
-quantity limit
-CNS stimulation
-SR and ER products do not last as long as they say
phenylephrine
Sudafed PE
bad oral decongestant
immediate release phenylephrine tablets
10mg q 4 h
MAX 6 doses/day
oral decongestants contraindications
-antidepressant drugs MAO inhibitors
-cardiovascular disease
-pregnancy
decrease milk production
pseudoephedrine is okay in pregnancy but it is known to ____________________________
TOPICAL nasal decongestants
vasoconstrictors that act locally on nasal mucosa and act quickly
oxymetazoline
Afrin, topical decongestant
use every 10-12 hours
MAX 2 doses in 24 hours
Cautions for Topical Nasal Decongestants
-cardiovascular disease
-enlarged prostate that causes urination issues
-rebound congestion
3 days
topical nasal decongestant sprays should not be used for more than ________________ due to risk of rebound congestion
rhinitis medicamentosa
Rebound congestion from overuse of nasal decongestants.
levmetamfetamine
Vicks Vapo Inhaler
Topical Decongestant
MAX 7 day use due to rebound congestion
propylhexadrine
Benzedrex
topical decongestant vapor inhaler
MAX 3 day use due to rebound congestion
3 months
once a vapor inhaler is opened it MUST be used within ____________________
OKAY
vapor inhalers for nasal decongestion are ______________ in cardiovascular disease
symptom
a cough is a ____________ and NOT a disease
productive cough
Cough that produces mucus or phlegm
you do NOT want to suppress this type of cough
non-productive cough
a dry cough without secretions
OKAY to suppress this type of cough
expectorants/protussive ingredients
encourages coughing up mucus in a productive cough
guaifenesin
Mucinex, Robitussin
expectorant
MAX 2400mg/day
age for guaifenesin
>4 years old
guaifenesin adverse effects
-nausea
-GI upset
a full glass of water
guaifenesin MUST be taken with ______________________
cough suppressant (antitussive ingredient)
can only be used in a dry/unproductive cough
dextromethorphan
Delsym
antitussive cough suppressant
can be addictive at very high doses
age for dextromethorphan
>4 years old
dextromethorphan contraindications
-MAO-I antidepressants (14 days)
-increases risk of serotonin syndrome
-MUST be 18 to purchase
common cold characteristics
-gradual onset
-low grade fever (less than 100)
-runny nose and congestion very common
influenza characteristics
-sudden onset
-high grade fever (102-104)
-headache and myalgia present
-extreme fatigue
-non productive dry cough
high risk people for influenza
-65 years or older
-anyone with a chronic medical condition
-pregnant women
-young children
ibuprofen age
6 months and older
acetaminophen age
2 years and older
2nd gen antihistamines age
2 years and older
oral decongestants age (sudafed, phenylephrine)
4 years and older
cough products age (guafenasin, dextromethorphan)
4 years or older
1st gen antihistamines age
6 years or older
naproxen age
12 years and older
dyspepsia
epigastric discomfort, also called indigestion
heartburn
warm or burning sensation in the chest which may spread to the neck/throat and occasionally to the back
episodic/intermittent heartburn
occurs infrequently or only occasionally
frequent heartburn
2 or more days per week
GERD (gastroesophageal reflux disease)
disease with symptoms and/or esophageal tissue damage resulting from abnormal reflux of stomach acid into the esophagus
symptoms of GERD
-frequent heartburn (2 or more days/week) lasting for 3 or more months
-regurgitation
-water brash (mouth fills with saliva)
DO NOT self treat these heartburn pts
-frequent heartburn lasting more than 3 months
-persistent heartburn even after otc drug treatment
-heartburn that continues after 2 weeks of H2RA or PPIs
-SEVERE heartburn
-heartburn that interrupts sleep
-anyone 45 years old (or older) with new onset symptoms
heartburn treatment goals
-relief of existing symptoms
-reduce symptom reoccurrence
non-drug therapy for heartburn
-avoid dietary triggers
-avoid large meals
-avoid laying down 2-3 hours after eating
-elevate the head of the bed
-lifestyle changes (weight loss, stop smoking, limit caffeine/alcohol)
OTC drug therapy for heartburn
-antacids
-H2 receptor antagonists
-proton pump inhibitors (PPIs)
antacids
neutralize the gastric acid to help symptoms of heartburn
antacids characteristics
-FAST onset
-SHORT acting
types of antacids
-calcium carbonate
-magnesium hydroxide
-aluminum hydroxide
-sodium bicarbonate
calcium carbonate
Tums, antacid for heartburn
can also be used as a calcium supplement
magnesium hydroxide
milk of magnesia, antacid for heartburn
causes diarrhea!
aluminum hydroxide
Amphogel, antacid for heartburn
causes constipation!
sodium bicarbonate
baking soda, antacid for heartburn
most rapid acting but not recommended due to increased gas and risk of gastric rupture
treatment
antacids are only FDA approved for the _______________ of heartburn and NOT the prevention
ANC
acid neutralizing capacity
scale used to measure antacids and their ability to neutralize gastric acid
best antiacid in regards to ANC
calcium carbonate (TUMS)
antacids onset
5 minutes
antacids counseling
chew thoroughly followed with a full glass of water
rolaids
calcium carbonate + magnesium hydroxide
antacids duration
20-30 mins
can be increased to 3 hours if taken with food
antacids drug interactions
can impact absorption of other meds, separate from other drugs 2-4 hours
antacids okay in pregnancy
-calcium
-magnesium
14 days
calcium and magnesium antacids can only be used for ______________ in pregnant women
alginic acid
Gaviscon
forms a barrier or raft in stomach for 4 hours if the person remains in an upright position
H2 receptor antagonists
reversibly bind to H2 receptors on parietal cells to decrease secretion of gastric acid
H2RA duration
slight delayed onset (1 hour) but longer duration of action
treat AND prevent
H2RAs are FDA approved to ______________________ heartburn
H2RAs products
-famotidine (Pepcid)
-cimetidine (Tagamet)
Ranitidine (Zantac)
H2 receptor antagonist that was taken off the market due to presence of NDMA
cimetidine drug interactions
-warfarin
-theophylline
-phenytoin
H2RAs age
12 years or older
proton pump inhibitors (PPIs)
irreversibly bind to actively working H/K/ATPase (proton pump) of parietal cells to block final step in acid secretion