Respiratory Care Pharmacology Chapter 16: Selected Agents of Pulmonary Value

-Alpha1-proteinase inhibitor

-Smoking cessation drugs

-Pulmonary vasodilators

name the 3 categories of drugs used for the direct treatment or prevention of respiratory disease

API (alpha1-antitrypsin)

what is administered to treat a1-antitrypsin deficiency?

alpha1-antitrypsin deficiency

genetic defect that leads to the development of severe panacinar emphysema

Panacinar emphysema

disease that destroys the entire alveolus uniformly and is predominant in the lower half of the lungs; caused by alpha1-antitrypsin deficiency.

FALSE: Alpha1-proteinase inhibitors are only indicated for panacinar emphysema; They are not indicated for smoking related emphysema.

True or False: alpha1-proteinase inhibitors are indicated for congenital, panacinar emphysema AND smoking-related emphysema

-Aralast

-Prolastin

-Zemaira

-Glassia

name the 4 alpha1-proteinase inhibitor drugs

No

Can a1-proteinase inhibitor medications reverse damage or improve lung function?

human plasma; risk of disease transmission.

where are a1-proteinase inhibitors derived from? what is the potential risk of this?

cigarette smoking

what is the leading cause of COPD?

True

True or False: Nicotine increases levels of dopamine, norepinephrine, acetylcholine, serotonin, and other substances

Nicotine polacrilex

formulated to allow the controlled release of nicotine into the body

-chewing gum

-lozenge

-nasal spray

-inhaler

name the 4 formulations of nicotine polacrilex

nicotine transdermal system

multilayered unit that delivers nicotine for 24 hours after application to the skin

-Bupropion

-Varenicline

-Clonidine

-Nortryptyline

name 4 generic non-nicotine smoking cessation medications

Buproprion

generic name for Wellbutrin, Zyban

Varenicline

generic name for Chantix

Clonidine

generic name for Catapres

Nortryptyline

generic name for Aventyl, Pamelor

Nitric Oxide

gas that is inhaled in conjunction with ventilatory support; acts as a pulmonary vasodilator

Persistent Pulmonary Hypertension in Newborns (PPHN)

what neonatal condition is nitric oxide approved to treat?

False: NO causes smooth muscle relaxation

True or False: Nitric oxide caused smooth muscle constriction

20 ppm

what is the recommended dose of inhaled nitric oxide?

PPHN

inhaled prostacyclin is used to treat...

-Iloprost

-Treprostinil

Epoprostenol

name 3 generic prostacyclin analogs

Iloprost

generic name for Ventavis

Treprostinil

generic name for Orenitram

Epoprostenol

generic name for Flolan

True

True or False: Prostacyclin analogs treat pulmonary hypertension