serotonin syndrome

what is the triad of serotonin syndrome?

- mental status change

- autonomic hyperactivity

- neuromuscular abnormalities

which drugs can cause serotonin syndrome?

- SSRIs

- MAOIs

- tricyclic antidepressants

- tramadol

- MDMA

- cocaine

- amphetamines

- triptans

what comes under autonomic hyperactivity?

- hyperthermia

- tachycardia

- hypertension

- mydriasis

- diaphoresis

what are the neuromuscular abnormalities?

- tremor

- clonus

- myoclonus

- hyperreflexia

- siezures

what comes under mental status change?

- confusion

- anxiety

- agitation

- restlessness

- disorientation

what is the management of serotonin syndrome?

- discontinue offending drug

- supportive care to stabilise - IV fluids

what is the antidote used in severe cases?

cyproheptadine or chlorpromazine - serotonin antagonists